N,N'-Methylenebisacrylamide Cas: 110-26-9 98% budo cad
| Lambarka buugaagta | XD90231 |
| Magaca Alaabta | N,N'-Methylenebisacrylamide |
| CAS | 110-26-9 |
| Qaanuunka molecular | C7H10N2O2 |
| Miisaanka Molecular | 154.1665 |
| Faahfaahinta Kaydinta | 2 ilaa 8 °C |
| Xeerka Tarifka La Iswaafajiyay | 29241900 |
Tilmaamaha Alaabta
| Qiimayn | >98% |
| Biyo aan milmi karin | <0.5% |
| Muuqashada | budo cad |
| Sulfates aan organic ahayn | <0.5% |
| Isticmaalka cilmi-baarista oo keliya, maaha isticmaalka aadanaha | cilmi baadhida loo isticmaalo oo kaliya, ee aan loo isticmaalin bini aadamka |
Doorka muhiimka ah ee fibroblasts-ku-xiran buro (TAF) ee horumarka kansarka ayaa hadda ku cad kansarka sambabada unugyada yaryar (NSCLC).Si kastaba ha ahaatee, daawaynta ka dhanka ah TAF-yada ayaa xaddidan sababtoo ah faham la'aanta hababka gaarka ah ee nooca hoose ee ka hooseeya ururintooda.Halkan, makaanikada (ie, matrix adkeysiga) iyo tilmaamo mitogenic milmaya oo kaxeeya ururinta TAF-yada ee noocyada waaweyn ee NSCLC: adenocarcinoma (ADC) iyo kansarka unugyada squamous cell (SCC) ayaa la kala saaray.Fibroblasts waxaa lagu soo barbaariyay substrata injineernimada si ay u muujiyaan qallafsanaanta caadiga ah ama burooyinka u eg ee uruurinta serum kala duwan, iyo hababka sharciyeynta muhiimka ah ayaa la soo bandhigay.Xakamaynta fibroblasts-ka unugyada aan fiicneyn, matrix adag oo kali ah ayaa kordhay isku-ururinta fibroblast-ka, iyo saameynta farsamadani waxay ahayd mid awood badan ama la barbar dhigi karta arrimaha koritaanka milmay ilaa 0.5% serum.Tilmaamaha kicinta ee adkeynta matrixka waxaa waday β1 integrin mechano-dareenka iyada oo loo sii marayo FAK (pY397), waxaana lala xiriiriyay iyada oo ha ka dib markii ay kor u kacday muujinta β1 integrin.Mechano-regulatory circuit-ka dambe ayaa sidoo kale lagu arkay TAF-yada laakiin qaab-hoosaad-gaar ah, sababtoo ah SCC-TAFs waxay soo bandhigeen FAK sare (pY397), muujinta β1, iyo ERK1/2 (pT202/Y204) marka loo eego ADC-TAFs.Intaa waxaa dheer, adkaanta matrixku waxay keentay ururinta TAF weyn ee SCC-TAFs (>50%) marka la barbar dhigo ADC-TAFs (10%-20%).Taas bedelkeeda, SCC-TAFs ayaa si weyn looga dareemay serum, halka ADC-TAFs ay ka jawaabeen uruurinta serum sare oo keliya.Natiijooyinkani waxay bixinayaan caddaynta ugu horreysa ee nidaamka-hoosaadka gaarka ah ee ururinta NSCLC-TAF.Intaa waxaa dheer, xogtani waxay taageertaa in daawaynta ujeedadeedu tahay in lagu soo celiyo dabacsanaanta sambabada caadiga ah iyo/ama β1 qawaaniinta mechano-ku-tiirsanaanta integrin-ku waxay noqon kartaa mid wax ku ool ah oo ka dhan ah SCC-TAFs, halka joojinta calaamadaha koritaanka stromal ay waxtar u yeelan karaan ADC-TAFs. ururinta aan caadiga ahayn ee buro-taageerta fibroblasts ee labada nooc ee waaweyn ee kansarka sanbabada, kaas oo gacan ka geysan doona horumarinta daawaynta shakhsi ahaaneed ee ka dhanka ah unugyadan.
