Alaabta

Beddelka dheef-shiid kiimikaad ee triglyceride (TG) ee unugyada muruqyada siman ee xididdada dhiigga (SMC) waxay u badan tahay inay la xiriirto phenotype gaar ah, inkasta oo tan aan la caddayn.Adipose triglyceride lipase (ATGL) waxay ka shaqeysaa firfircoonida firfircoon ee TG ee unugyada adipotic iyo non-adipotic.Daraasadda hadda jirta, waxaan SMC ka soocay jiirarka ATGL-deficient (ATGL(-/-) mSMC).ATGL (-/-) mSMC waxay muujisay isu-ururinta TG-ga oo leh jawaab-celin hoose oo mitogenic ah iyo muujinta muruqa siman (SMA) marka la barbar dhigo ATGL (+/+) mSMC.Boqolkiiba unugyada togan ee _-galactosidase ee la xidhiidha miyir-qabka ayaa sidoo kale lagu kordhiyey ATGL(-/-) mSMC.PCR-waqtiga-dhabta ah oo ay ku xigto baadhista falanqaynta falanqaynta DNA-da ee diiradda saareysa muujinta habaysan ee glucokinase (1.7-laab), lipoprotein lipase (3.8-laab) iyo interleukin-6 (3.7-laab) iyo muujinta hoos-u-xun ee koritaanka xididdada xididdada dhiigga factor-A (0.2-laab), nooca I kolajka (0.5-laab), iyo isbeddelka factor koritaanka -_ (0.4-laab) ee ATGL (-/-) mSMC marka la barbar dhigo ATGL(+/+) mSMC.Marka xigta, wareejinta hiddasidaha ectopic ee ATGL aadanaha ayaa la isku dayay iyadoo la adeegsanayo doxycycline (Dox) -lagu maamuli karo myc-DDK-tagged adenovirus vector (AdvATGL).Caabuqa AdvATGL wuxuu keenay hoos u dhaca ururinta TG oo leh jawaab celin mitogenic ah oo sare leh iyo muujinta SMA, iyo hoos u dhaca tirada unugyada dareenka ee ATGL (-/-) mSMC.Waxaa intaa dheer, hannaankii muujinta hidde-sidaha leexsan ee ATGL(-/-) mSMC ayaa si macquul ah loo saxay.Xogtayadu waxay soo jeedinaysaa in ATGL(-/-) mSMC ay leedahay phenotype gaar ah oo laga yaabo inay la xiriirto pathogenesis vascular.Plasticity of phenotypes SMC ee la xidhiidha dheef-shiid kiimikaadka dufanku waxay noqon kartaa bartilmaameed daweyn.