Alaabta

Nickelku waa calaamad muujinaysa fayraska bakteeriyada Helicobacter pylori.Runtii, H. pylori waxa ay leedahay laba nikkel-enzymes oo lagama maarmaan u ah gumeysiga vivo, [NiFe] hydrogenase iyo urease, oo ah cunsur fayrus badan leh oo ka kooban 24 ion nikkel halkii dhisme kasta oo firfircoon.Sababtoo ah labadan ensaymes, badbaadada H. pylori waxay ku tiirsan tahay sahayda muhiimka ah ee nikkel, taasoo tuseysa xakameyn adag oo qaybinteeda iyo kaydinteeda.Dib u eegistaan, waxaan ku soo bandhigi doonaa wadooyinka firfircoonida enzymes nikkel iyo sidoo kale hababka asalka ah ee laga helo H. pylori ee qaadashada, ka ganacsiga iyo qaybinta nikkel inta u dhaxaysa labada enzymes.Kuwaas waxaa ka mid ah (i) nidaamka kor-u-qaadista nikkel-xub-baxa, FrpB4 TonB-ku-tiirsanaanta, (ii) isku-dhafka borotiinka iyo shabakadaha isdhexgalka ee ku lug leh ka ganacsiga nikkel iyo qaybinta u dhaxaysa urease iyo hydrogenase iyo, (iii) Helicobacter borotiinno gaar ah oo nikkel ah kuwaas oo ku lug leh kaydinta nikkel oo ciyaari kara doorka metallo-chaperones.Ugu dambayntii, waxaanu ka wada hadli doonaa saamaynta ay la-hawlgalayaasha ka-ganacsiga nikkelku ku leeyihiin fayraska waxaana u soo jeedin doonnaa inay noqdaan bartilmaameedyo daweyn oo cusub oo loogu talagalay daawaynta ka dhanka ah caabuqa H.pylori.