Alaabta

C6 dicarboxylic acid, adipic acid, waa kiimiko madal muhiim u ah warshadaha.Wax-soo-saarka biobased ee adipic acid waa beddel rajo leh oo beddelka jidka petrochemical ee hadda.Halkan, waxaanu kaga warbixinaynaa biosynthesis ee adipic acid anagoo adeegsanayna dariiq macmal ah oo ay dhiirigelisay dib u noqoshada beta-oxidation ee acids dicarboxylic.Jidka biosynthetic wuxuu ka kooban yahay uumiga acetyl-CoA iyo succinyl-CoA si loo sameeyo laf dhabarta C6 iyo dhimista ku xigta, fuuqbaxa, hydrogenation, iyo sii deynta adipic acid ka thioester.Dariiqa waxaa markii ugu horeysay lagu tijaabiyay in vitro iyadoo dib loo habeeyay enzymes dariiqa ka dibna si shaqeyneysa loo soo geliyay Escherichia coli si ay biosynthesis iyo uga soo saarta adipic acid dhexda dhaqanka.Titer-ka wax-soo-saarka ayaa lagu kordhiyey ku dhawaad ​​20-laab iyada oo loo marayo isku-darka qorista enzymes kuwaas oo aad ugu habboon in lagu kiciyo falcelinta synthetic iyo kordhinta helitaanka substrate-ka uumiga.Shaqadani waxay muujinaysaa biosynthesis tooska ah ee adipic acid iyada oo loo marayo dariiqa synthetic ee aan dabiiciga ahayn, taas oo awood u siin karta wax soo saarkeeda la cusboonaysiin karo.