6-Chloropurine CAS: 87-42-3 budada jaalaha ah ee fudud
| Lambarka buugaagta | XD90547 |
| Magaca Alaabta | 6-Chloropurine |
| CAS | 87-42-3 |
| Qaanuunka molecular | C5H3ClN4 |
| Miisaanka Molecular | 154.557 |
| Faahfaahinta Kaydinta | 2 ilaa 8 °C |
| Xeerka Tarifka La Iswaafajiyay | 2933990090 |
Tilmaamaha Alaabta
| Muuqashada | budo huruud ah oo khafiif ah |
| Qiimayn | 99% |
Waxaan dhawaan soo sheegnay in pyrene nucleotide sida doorbidan la geliyo ka soo horjeedka goobta aasaasiga ah, 3'-T ee dimer thymine, iyo saldhigyada ugu badan ee aan waxyeelo gaarin khamiir DNA polymerase eta (pol eta).Sababtoo ah pyrene waa molecule nonpolar oo aan lahayn karti-ku-xidhid H, waxtarka aan caadiga ahayn ee sarreeya ee gelinta dPMP waxaa lagu tiriyaa awoodda isugeynta sare ee saldhigga, waxayna hoosta ka xariiqaysaa muhiimada isugeynta saldhigga xulashada nucleotides by pol eta.Si loo baaro doorka H-bonding iyo saldhigga joomatari ee xulashada nucleotides by pol eta, waxaan go'aaminnay waxtarka gelinta ee nucleotides-ka-beddelka ah ee 2,6-diaminopurine, 2-aminopurine, 6-chloropurine, iyo inosine kuwaaso samee tiro kala duwan oo H-bonds ah oo leh saldhigga template iyadoo ku xiran joomatari lammaane sal ah.Isku-dhafka saldhigga Watson-Crick wuxuu u muuqdaa inuu door muhiim ah ka ciyaaro xulashada analogues nucleotide ee gelinta ka soo horjeeda C iyo T sida lagu caddeeyey hoos u dhaca waxtarka gelinta qaraabada leh hoos u dhaca tirada Watson-Crick H-bonds iyo korodhka tirada deeq-bixiye-ku-deeqaha iyo is-dhexgalka aqbal- aqbalayaasha.Xulashada gelinta nucleotide ayaa ka soo horjeeda 5'-T marka loo eego 3'-T ee dimer thymine, iyadoo la raacayo shaqadii hore ee soo jeedinaysa in 5'-T loo hayo si ka adag kan 3'-T.Intaa waxaa dheer, gelinta A ka soo horjeeda labada Ts ee dimer waxay u muuqataa in ay dhexdhexaadinayaan isku-dhafka saldhigga Watson-Crick ee ma aha saldhigga Hoogsteen ee ku salaysan waxtarka gelinta isku midka ah ee A iyo 7-deaza-A, kan dambe kaas oo ka maqan H- awoodda isku xidhka ee N7.Waxtarka qaraabada ah ee gelinta nucleotides ee samayn kara lammaane saldhig Watson-Crick barbar socda kuwa jajabka Klenow, halka jajabka Klenow uu si xooggan u takooro is-dheellitirka, iyada oo la raacayo xulashada qaabkeeda weyn.Natiijooyinkani waxay hoosta ka xarriiqeen muhiimadda ay leedahay labada lammaane ee H-bonding iyo Watson-Crick ee xulashada nucleotides-ka labadaba pol eta iyo Klen ow fragment, iyo doorka yar ee xulashada qaabka gelinta by pol eta sababtoo ah aad u furan oo yar goobta firfircoon ee xaddidan.
