Alaabta

Daawaynta unugyada naasleyda ee leh dawooyinka kiimiko-daawaynta waxay keeni kartaa khalkhal ku yimaada barkadaha nucleotide.La socodka dhibaatooyinkan unugyada burooyinka dhaqameed ee laga helo ilaha bini'aadamka ayaa faa'iido u leh qiimeynta saameynta daaweynta daroogada iyo fahamka wanaagsan ee habka ficilka daawooyinkan.Daraasaddan, saddex qaybood oo ah dawooyinka kiimikaad oo leh habab kala duwan oo ficil ah ayaa loo adeegsaday horumarinta moodooyinka unugyada la daweeyay.Falanqaynta metabolomics-ku-salaysan ee LC-ku-salaysan ee nucleotides-ka ee unugyada kooxda xakamaynta iyo kooxda dawada la daweeyay ayaa la fuliyay.Hababka habaynta xogta dhowr ah ayaa la isku daray si loo aqoonsado biomarkers-ka suurtagalka ah ee la xidhiidha ficilka daawooyinka, oo ay ku jiraan falanqaynta hal-dhinac ee kala duwanaanshiyaha, falanqaynta qaybta aasaasiga ah, iyo qaloocyada sifada hawl-qabashada qaataha.Si xiiso leh, unugyada burooyinka ee kooxda kantaroolka iyo kooxaha daroogada lagu daaweeyay waa la kala saari karaa midba midka kale, doorsoomayaal dhowr ah ayaa loo aqoonsaday inay yihiin potentia l biomarkers, sida ATP, GMP, iyo UDP ee wakiilada antimetabolite, ATP, GMP, iyo CTP loogu talagalay wakiilada waxyeelada DNA-da, iyo sidoo kale GMP, ATP, UDP, iyo GDP ee wakiilada lafdhabarta mitotic.Ansixinta dheeraadka ah ee biomarkers-ka suurtagalka ah ayaa la sameeyay iyadoo la adeegsanayo qalooca sifada hawl-qabashada qaataha.Iyadoo la tixgelinayo aagga u dhigma ee ka hooseeya qalooca, kaas oo ka weynaa 0.9, waxaa lagu soo gabagabeyn karaa in GMP iyo ATP ay yihiin kuwa ugu wanaagsan ee biomarkers ee daawooyinka waxyeellada DNA-da, iyo sidoo kale GMP, ATP, iyo UDP ee labada qaybood ee kale ee daroogooyinka.Habkan xaddidan ee nucleotide si buuxda uma kala saari karo hababka sagaalka daawo, laakiin waxay bixisaa caddayn horudhac ah oo ku saabsan doorka pharmacometabolomics ee horumarinta hore ee daawooyinka ugu yaraan.