Spiramycin Cas: 8025-81-8
| Lambarka buugaagta | XD90452 |
| Magaca Alaabta | Spiramycin |
| CAS | 8025-81-8 |
| Qaanuunka molecular | C43H74N2O14 |
| Miisaanka Molecular | 843.05 |
| Faahfaahinta Kaydinta | 2 ilaa 8 °C |
| Xeerka Tarifka La Iswaafajiyay | 29419000 |
Tilmaamaha Alaabta
| Muuqashada | Budada Cad |
| Qiimayn | >4100IU/mg |
| Biraha culus | <20pm |
| Khasaare xagga qallajinta | <3.5% |
| Sulfated Ash | <1.0% |
| Ethanol | <2.0% |
| Wareegga indhaha ee gaarka ah | -85 ilaa -80 deg; |
Streptomyces ambofaciens waxay soo saartaa antibiyootiga macrolide spiramycin.Kooxda hiddo-wadaha biosynthetic ee spiramycin ayaa lagu sifeeyay S. ambofaciens.Marka lagu daro hidda-wadaha nidaaminta ee srmR (srm22), oo hore loo aqoonsaday (M. Geistlich et al., Mol. Microbiol. 6:2019-2029, 1992), saddex hiddo-wadeyaal nidaamin ah ayaa lagu aqoonsaday falanqayn isku xigxigay.Falanqaynta muujinta hidda-wadaha iyo tijaabooyinka firfircoonida hidda-wadaha waxay muujiyeen in mid ka mid ah saddexdan hidde-side, srm40, uu door weyn ka ciyaaro nidaaminta biosynthesis ee spiramycin.Burburinta srm22 ama srm40 waxay meesha ka saartay wax soo saarkii spiramycin halka ay si xad dhaaf ah u muujinayeen ay kordhisay wax soo saarka spiramycin.Falanqaynta muujinta waxaa lagu sameeyay dib-u-celinta-PCR (RT-PCR) dhammaan hiddo-wadaha kooxda kutlada nooca duurjoogta ah iyo srm22 (srmR) iyo srm40 mutants tirtiridda.Natiijooyinka ka soo baxay falanqaynta muujinta, oo ay weheliyaan kuwa ka soo baxay tijaabooyinka dhammaystirka, ayaa muujiyay in Srm22 looga baahan yahay srm40 muujinta, Srm40 oo ah hawl-wadeen waddo-gaar ah oo kontaroolaysa inta badan, haddaysan ahayn dhammaan, hiddo-wadaha biosynthetic spiramycin.
