Alaabta

BBS4 waa mid ka mid ah borotiinno dhowr ah oo cilladahooda ay sababaan Bardet-Biedl syndrome (BBS), cillad nidaamsan oo badan, oo ka muuqda buurni calaamadeysan.BBS4 polymorphisms ayaa lala xiriiriyay buurnaanta jirrooyinka caadiga ah ee aan cillad lahayn.Hababka molecular-ka buurnaanta ee BBS4, iyo doorka hidda-wadaha BBS4 ee kala-duwanaanta adipocyte iyo shaqada si buuxda looma yaqaan.Waxaan hadda tusineynaa in Bbs4 ay ka ciyaarto door toos ah oo lama huraan u ah faafinta iyo adipogenesis: aamusnaanta Bbs4 ee 3T3F442A preadipocytes waxay keentay qaybinta unugyada degdega ah iyo kala soocida aberrant, oo cad iyada oo loo marayo daraasadaha morphologic (iftiin, iskaanka iyo gudbinta microscopy elektarooniga), falanqaynta dheef-shiid kiimikaadka (ururinta dufanka, Aashitada dufanka leh iyo lipolysis) iyo qoraallada calaamadaha adipogenic (Cebpα, Pparγ, aP2, ADRP, Perilipin).Inta lagu jiro adipogenesis-ka iyo marka culeyska dufanka la saaro, unugyada aamusan ee Bbs4 waxay ururiyaan triglycerides si aad ah uga badan kan kantaroolka adipocytes, inkastoo ay ka yar yihiin (weli tiro badan) dhibco ay ku jiraan astaamaha aashitada dufanka leh ee la beddelay.Sidaa darteed, ururinta dufanka weyn ee unugyada aamusan ayaa ah natiijada labadaba heerka sare ee faafinta adipocyte iyo kala soocida aberrant taasoo horseedaysa ururinta aberrant ee baruurta unug kasta.Natiijooyinkayagu waxay soo jeedinayaan in buurnida BBS laga yaabo inay qayb ahaan sabab u tahay doorka tooska ah ee BBS4 ee hababka jireed iyo jireed ee hoosta ka dhigaya samaynta unugyada adipose ee khuseeya buurnaanta.