Guanosine-5′-diphosphate, cusbada disodium Cas:7415-69-2 budo cad 98%
| Lambarka buugaagta | XD90756 |
| Magaca Alaabta | Guanosin-5'-diphosphate, cusbo disodium |
| CAS | 7415-69-2 |
| Qaanuunka molecular | C10H13N5Na2O11P2 |
| Miisaanka Molecular | 487.16 |
| Faahfaahinta Kaydinta | -15 ilaa -20 °C |
| Xeerka Tarifka La Iswaafajiyay | 29349990 |
Tilmaamaha Alaabta
| Muuqashada | budo cad |
| Qiimayn | >99% |
| Biyo | <10% |
RasGrf1 iyo RasGrf2 waa naasleyda guanine nucleotide isweydaarsiga naasleyda aadka isku midka ah kuwaas oo awood u leh inay dhaqaajiyaan Ras ama Rho GTPases gaar ah.Hidde-sidayaasha RasGrf ayaa si gaar ah loogu muujiyay habka dhexe ee neerfayaasha, inkasta oo muujinta gaarka ah ee goobta midkoodna laga yaabo inay ka dhacdo meelo kale.RasGrf1 waa hidde-sidaha aabbaha la muujiyey, oo la daabacay oo la muujiyey dhalmada kaddib.Taas bedelkeeda, RasGrf2 ma daabacan oo waxay tusinaysaa hannaan hadal oo ballaadhan.Kala duwanaanshaha isoforms ee labada hiddo-sidaha ayaa sidoo kale lagu ogaan karaa xaaladaha kala duwan ee unugyada.Borotiinnada RasGrf waxay soo bandhigaan qaab-dhismeedyo modular ah oo ay ka kooban yihiin qaybo badan oo ay ku jiraan CDC25H iyo DHPH motifs ee mas'uul ka ah horumarinta GDP/GTP beddelka, siday u kala horreeyaan, ee bartilmaameedyada Ras ama Rho GTPase.Qaybaha kala duwani waa lama huraan si loo qeexo dhaqdhaqaaqooda wax-is-weydaarsiga ah iyo in la beddelo gaar ahaaneed ee hawlahooda shaqo si ay ugu xidhaan calaamadaha kala duwan ee kor u kaca bartilmaameedyada kala duwan ee hoose iyo jawaabaha gacanta.In kasta oo ay isku mid yihiin, RasGrf1 iyo RasGrf2 waxay soo bandhigaan tilmaamo gaar ah oo bartilmaameedyo ah iyo doorar shaqo oo aan is-dul-saarnayn oo kala duwan oo tilmaameyaal ah oo la xiriira koritaanka unugyada iyo kala duwanaanta iyo sidoo kale dareenka neuronal iyo jawaabta ama balaastiga synaptik.Halka labada RasGrfs ay firfircoon yihiin soo-dhoweeyayaasha glutamate-ka, G-protein-ku-ku-xidhan-qaadayaasha ama isbeddelada xoojinta calcium ee unugyada, kaliya RasGrf1 ayaa lagu soo warramey in ay dhaqaajiso LPA, cAMP, ama agonist-firfircoon Trk iyo cannabinoid reseptors.Falanqaynta noocyada kala duwan ee jiirarka garaaca ayaa daaha ka qaaday waxqabad gaar ah oo ka mid ah RasGrf1 ee hababka xusuusta iyo barashada, soo dhaweynta sawir-qaadista, xakamaynta koritaanka dhalmada ka dib iyo cabbirka jirka iyo shaqada β-unugga ganaca iyo gulukooska homeostasis.RasGrf2, doorarka gaarka ah ee fidinta lymphocyte, jawaabaha calaamadaha T-unugga iyo lymphomagenesis ayaa lagu sifeeyay.
