Alaabta

Mid ka mid ah habka daaweynta ee muhiimka ah ee daaweynta nooca 2 ee sonkorowga mellitus waa isticmaalka wakiilada hoos u dhigi kara hyperglycaemia postprandial iyadoo la joojinayo enzymes dheefshiidka karbohaydraytyada.Daraasadda hadda jirta waxay baartay saameynta soosaarka bioassay-hagaha iyo jajabyada miraha qallalan ee pericarp ee Phaleria macrocarpa, oo ah warshad dhaqameed ka hortagga sonkorowga, oo ku saabsan α-glucosidase iyo α-amylase, si ay u fahmaan habka ka hortagga sonkorowga, sida Sidoo kale ficilkooda attenuation ee suurtogalka ah ee korodhka gulukooska postprandial. Soosaarida methanol (ME), oo lagu helay soo saarista dareeraha isku xigta, jajabkeeda dareeraha-dareere n-butanol (NBF) iyo qaybta hoose ee chromatographic (SFI), ayaa la qiimeeyay loogu talagalay in vitro α-glucosidase (khamiir) iyo α-amylase (porcine) joojinta dhaqdhaqaaqa.Intaa waxaa dheer, imtixaannada xaqiijinta ee vivo ayaa lagu sameeyay streptozotocin-induced diabetes jiirka (SDRs) iyadoo la adeegsanayo gulukooska afka, sukrose iyo imtixaanada dulqaadka istaarijka.Xeerka ugu sarreeya ee la shaqaaleysiiyay (1 00 μg / ml), NBF waxay muujisay xakamaynta ugu sareysa ee ka dhanka ah α-glucosidase. 75%) iyo α-amylase (87%) in vitro (IC50 = 2.40 ± 0.23 μg/ml iyo 58.50 ± 0.13 μg/ml, siday u kala horreeyaan) ee qaabka qiyaasta qiyaasta;Saamaynta lagu ogaaday in ay ku saabsan tahay 20% ka sarreeya acarbose (55%), heerka α-glucosidase inhibitor (IC50 = 3.45 ± 0.19 μg / ml).ME iyo SFI waxay sidoo kale joojiyeen α-glucosidase (IC50 = 7.50 ± 0.15 μg/ml iyo 11.45 ± 0.28 μg/ml) iyo α-amylase (IC50 = 43.90 ± 0.19 μg/ml iyo 69.82 ± g) xad ka yar.Daraasadaha vivo ee jiirka macaanka, NBF iyo SFI waxay si wax ku ool ah u yareeyeen gulukooska dhiigga ee ugu sarreeya (PBG) 15.08% iyo 6.46%, iyo aagga ku hoos jira qalooca dulqaadka (AUC) 14.23% iyo 12.46%, siday u kala horreeyaan, ka dib tartan sukrose afka ah (P <0.05);taas oo lagu ansixinayo ficilka vitro ee lagu arkay.Saamayntan hoos u dhigista ee PBG iyo AUC ayaa sidoo kale lagu muujiyay tijaabooyinka dulqaadka gulukooska iyo istaarijka, laakiin heerar ka yar. Natiijooyinkani waxay muujinayaan in P. macrocarpa ay hoos u dhigi karto hyperglycaemia labadaba gudaha vitro iyo xaaladaha vivo iyagoo si xooggan u xakameynaya carbohydrate hydrolysing enzymes, taas oo ka dhigaysa. Warshad wax ku ool ah oo laga helo xeryahooda dabiiciga ah ee maaraynta nooca 2aad ee sonkorowga mellitus.