Alaabta

Neuroblastoma, kansarka habdhiska dareenka, waa burada adag ee ugu badan ee carruurta ku dhacda.Kordhinta MYCN iyo kordhinta BDNF/TrkB calaamadaynta waa astaamaha burooyinka khatarta sare leh;haddana, kaliya ˜25% ee burooyinka halista ah ayaa muujiya sifooyinkan.Sidaa darteed, aqoonsiga biomarkers dheeraad ah iyo bartilmaameedyada daaweynta waa lagama maarmaan.Sida aminoacylase 1 (ACY1), amino acid deacetylase, waa buro xakameynaya unugyada yaryar ee sambabada iyo kansarka unugyada kelyaha, waxaan baarnay haddii aspartoacylase (ASPA, aminoacylase 2) ama aminoacylase 3 (ACY3) ay u adeegi karaan. shaqo la mid ah neuroblastoma.Muujinta Aminoacylase waxaa lagu baadhay TrkB-positive, MYCN-la xoojiyay (SMS-KCNR iyo SK-N-BE) iyo TrkB-negative, non-MYCN-la xoojiyay (SK-N-AS, SK-N-SH, SH-SY5Y iyo SH-EP) Khadadka unugyada neuroblastoma.Aminoacylase kasta waxa uu soo bandhigay meelayn gaar ah (sida, cytosolic ACY1, xuubka-xidhiidhka ASPA iyo nukliyeerka ACY3).Marka unugyada SK-N-SH lagu daaweeyay wakiilada kala soocida neerfaha (tusaale, retinoic acid iyo cAMP) ee warbaahinta ka kooban 10% serum, ACY1 waxay ahayd aminoacylase kaliya oo muujintiisa la hagaajiyay.ASPA waxaa ugu horrayn lagu muujiyay unugyada SH-EP ee gunta hoose ee glial.ACY3 si aad ah ayaa loogu muujiyay TrkB-positive, MYCN-la kordhiyay.Dhammaan saddexda aminoacylase waxaa lagu muujiyay qanjidhada adrenal ee bini'aadamka ee caadiga ah, oo ah goobta caadiga ah ee asalka neuroblastoma, laakiin kaliya ACY1 iyo ACY3 ayaa muujiyay muujinta la ogaan karo ee burada neuroblastoma aasaasiga ah.Macdanta xogta bioinformatics ee badbaadada Kaplan-Meier ayaa shaaca ka qaaday in muujinta sare ee ACY3 ay la xiriirto saadaasha liidata, halka muujinta hoose ee ACY1 ama ASPA ay la xiriirto saadaasha liidata.Xogtaasi waxay soo jeedinaysaa in muujinta aminoacylase lagu xakameynayo neuroblastoma