Alaabta

tRNA waa nooca aadka wax looga beddelay ee noocyada RNA, wax ka beddelkana waxaa laga helaa tRNA-yada dhammaan noolaha la baaray.In kasta oo ay aad u kala duwan yihiin qaab-dhismeedka kiimikada iyo joogitaanka tRNA-yada kala duwan, oo ka dhaca meelo kala duwan tRNA, dariiqyada biosynthetic ee badi wax ka beddelka tRNA waxaa ka mid ah tallaabo(s) methylation ah.Daah-furkii ugu dambeeyay ayaa muujiyay kakanaanta aan horay loo arag ee qaababka wax ka beddelka ee tRNA, nidaamintooda iyo shaqadooda, iyagoo soo jeedinaya in nucleoside kasta oo la beddelay ee tRNA uu yeelan karo hawl gaar ah.Si kastaba ha noqotee, dhirta, aqoontayada doorka wax ka beddelka tRNA ee shakhsi ahaaneed iyo sida loo habeeyo waa mid aad u xaddidan.Shaashadda hidde-sidaha ee loogu talagalay in lagu aqoonsado arrimaha xakameynaya iska caabbinta cudurrada iyo kicinta difaaca gudaha Carabidopsis, waxaan ku aqoonsannay KOOXAHA CSB3 9 (SCS9).Natiijooyinkayagu waxay daaha ka qaadayaan SCS9 waxay qeexaysaa tRNA methyltransferase kaas oo dhexdhexaadiya 2'-O-ribose methylation ee noocyada tRNA ee la doortay ee antico don loop.Isbeddelladan tRNA ee dhexdhexaadka ah ee SCS9 waxay kor u qaadaan muddada caabuqa ee bakteeriyada pathogene Pseudomonas syringae DC3000, iyo la'aanta wax ka beddelka tRNA, sida lagu arkay scs9 mutants, waxay si ba'an u wiiqaan difaaca dhirta ee isla cudur-sidaha iyada oo aan saameyn ku yeelan calaamadaha salicylic acid (SA) dariiqa xakameynaya jawaab celinta difaaca dhirta.Natiijooyinkayagu waxay taageerayaan tusaale siinaya muhiimada xakamaynta qaar ka mid ah isbeddelada tRNA ee kor loogu qaadayo jawaab-celinta difaaca wax ku oolka ah ee Arabidopsis, oo sidaas awgeed waxay ballaadhinaysaa repertoire ee qaybaha molecular ee lagama maarmaanka u ah jawaab-celin wax-ku-ool ah oo iska caabbinta cudurrada.