Vancomycin hydrochloride Cas: 1404-93-9 Caddaan ku dhawaad cad ama budo casuus ah
Lambarka buugaagta | XD90197 |
Magaca Alaabta | Vancomycin hydrochloride |
CAS | 1404-93-9 |
Qaanuunka molecular | C66H76Cl3N9O24 |
Miisaanka Molecular | 1485.7145 |
Faahfaahinta Kaydinta | 2 ilaa 8 °C |
Xeerka Tarifka La Iswaafajiyay | 29419000 |
Tilmaamaha Alaabta
Biyo | NMT 5.0% |
Biraha culus | NMT 30ppm |
pH | 2.5 - 4.5 |
Bakteeriyada endotoxins | NMT 0.33EU/mg ee Vancomycin |
Cadaynta Xalka | Cad |
Muuqashada | Caddaan, ku dhawaad cad, ama maan ilaa budo casaan ah |
Vancomycin B | NLT 85% |
Xadka monodechlorovancomycin | NMT 4.7% |
Qiimaynta (microbial, anhydrous based) | NLT 900ug/mg |
1. Dhacdooyinka caabuqa Staphylococcus aureus u adkaysta methicillin ee bulshadu heshay waxay ku socotaa xawli naxdin leh.Daawaynta waxtarka leh ayaa taariikh ahaan ku lug lahayd debridement hore iyo maamulka antibiyootiga.Daraasaddan waxaa loo qaabeeyey si loo go'aamiyo waxtarka daaweynta empiric ee daaweynta caabuqyada gacanta.Bukaanka qaba infekshanka gacanta ayaa la siiyay vancomycin xididka empiric marka la seexiyo ama cefazolin xididka ah.Natiijooyinka waxaa lala socday iyadoo la adeegsanayo darnaanta caabuqa, jawaab celinta caafimaad ee habboon, iyo muddada joogitaanka.Waxtarka-kharashka waxaa la xisaabiyay iyadoo la isticmaalayo wadarta kharashka bukaan kasta ee labada kooxood.Falanqaynta tirakoobka ayaa la sameeyay. Afartan iyo lix bukaan ayaa lagu qoray daraasadda.24 ayaa la kala soocay Cefazolin (52.2 boqolkiiba) iyo 22 (47.8 boqolkiiba) vancomycin.Ma jirin farqi xisaabeed oo u dhexeeya kharashka daawaynta (p <0.20) ama celceliska muddada joogista (p <0.18) betw een kooxaha.Bukaannada loo kala soocay cefazolin waxay lahaayeen kharashyo dhexdhexaad ah oo daaweyn ah marka loo eego bukaannada loo kala soocay vancomycin (p <0.05).Bukaanka qaba infekshannada aadka u daran waxay lahaayeen kharashyo daaweyn oo celcelis ahaan qaali ah (p <0.0001) iyo celcelis dheer oo joogitaan (p = 0.0002).Dhammaadkii daraasadda, dhacdooyinka ay bulshadu ka heshay methicillin u adkaysta S. aureus ee cisbitaalka gobolka qorayaasha ayaa la ogaaday inay tahay 72 boqolkiiba, taas oo sababtay in daraasadda ay joojiso wakhti hore guddiga dib u eegista hay'adaha sababtoo ah dhacdooyinka badan Daawaynta ugu horaysa ee ku haboon ee methicillin u adkaysata S. aureus si dhab ah looma dhisin.Ma jiro farqi u dhexeeya natiijada iyadoo la adeegsanayo cefazolin iyo vancomycin sida wakiilka safka hore ayaa la aqoonsaday.
2.Iyadoo la hagaajinayo bogsashada nabarrada iyada oo la adeegsanayo antibiyootiga ka hortagga xididada iyo hagaajinta farsamada, infekshannada suxulka qalliinka ka dib ayaa noqday kuwo aan caadi ahayn laakiin weli waxay ku dhacaan qalliinnada suxulka ee doorashada qaarkood.Ujeedada daraasaddan ayaa ahayd in la qiimeeyo badbaadada iyo waxtarka isticmaalka ka hortagga ah ee vancomycin ee goobta qalliinka si loo yareeyo dhacdooyinka caabuqa ka dib marka la sii daayo suxulada qallafsan ee ka dambeeya. muddo ayaa la sameeyay.Kooxda kantaroolka (93 bukaan), kahortag fudud oo leh antibiyootiga caadiga ah ee xididada ayaa la sameeyay;Kooxda vancomycin (bukaanada 179), budada vancomycin ayaa si toos ah loogu dabaqay nabarka ka hor inta aan la xidhin iyada oo la raacayo ka hortagga caadiga ah ee xididada. inta u dhaxaysa: 2.40%-13.52%) marka la barbar dhigo midna (0%; muddada kalsoonida: 0-2%04%) kooxda vancom ycin, taas oo ahayd farqi weyn oo tirakoobka ah (P = .0027).Wax saameyn ah oo xun lagama helin isticmaalka tooska ah ee budada vancomycin. Codsiga maxalliga ah ee budada vancomycin waxay noqon kartaa hab rajo leh oo looga hortagayo caabuqyada suxulka ka dib markii la sii daayo suxulka bukaanada qaba qallafsanaanta suxulka.