Alaabta

Dareemayaasha PH waxaa lagu sameeyay by anodically electrodepositing iridium oxide films (AEIROFs) oo dulsaaray microelectrodes chips oo lagu dahaadhay poly (ethyleneimine) (PEI) xasiloonida farsamada.Kuwani waxay muujinayaan jawaabta super-Nernstian ee pH ee pH 4.0 ilaa 7.7 ee kaydka fosfooraska-free kaloriinta.Dusha sare ee chip-ka waxaa lagu dahaadhay fibronectin si loogu xidho unugyada aortic endothelial porcine (PAECs).Awoodda shaqada ee dareemaha pH ee la socodka isbeddellada ba'an ee pH maxalliga ah ayaa lagu baaray iyada oo kicinaysa PAEC-yada leh thrombin.Natiijooyinkayagu waxay muujinayaan in trombobin ay keentay acidification-ka unugyada ka baxsan ee ba'an ee PAECs iyo kala dirida fibronectin, taasoo keentay in pH-ga maxalliga ah uu yaraado.Isticmaalka PD98059, mitogen-activated protein kinase (MAPK) inhibitor, hoos u dhigista acidification ka baxsan iyo kororka pH maxaliga ah ayaa la arkay.Daraasadani waxay muujinaysaa in dareemayaasha pH-yadayadu ay fududayn karaan baaritaanka jawaabaha degdega ah ee gacanta ee kicinta iyadoo la kormeerayo wakhtiga dhabta ah, isbeddelada pH ee unugyada ee ku xiran dareemayaasha.