Alaabta

Si loo baaro saameynta saliidda spearmint ee isbeddelada emphysema-sida iyo muujinta buro necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) iyo unugyada xakameynaya ee metalloproteinase -1 (TIMP-9) ee lipopolysaccharide (LPS) ee lagu daweeyay jiirkaJiirka ayaa loo kala qaybiyay xakamaynta, dexamethasone (0.3 mg x kg(-1)), iyo saliidda xabagta (10, 30,100 mg x kg(-1)) kooxo.Koox kasta waxaa lagu daweeyey cusbo, dexamethasone, iyo spearmint saliid ah siday u kala horreeyaan muddo 4 toddobaad ah.Dabadeed wadarta iyo tirada unugyada dhiigga cad ee kala duwan ee dareeraha fayraska bronchoalveolar (BALF) ayaa la sameeyay.Isbeddellada pathologic ee unugyada sambabada sida qaab-dhismeedka alveolar, caabuqa marin-haweedka, iyo metaplasia unugga goblet ayaa lagu arkay sheyga HE iyo AB-PAS.Muujinta TNF-alpha, IL-1beta, TIMP-1 iyo MMP-9 ayaa la qiyaasay.Labada xabaasha iyo dexamethasone waxay hoos u dhigeen burburinta alveolus sambabada.Wadarta iyo kala duwanaanta tirada unugyada dhiiga cad ee BALF oo ay ku jiraan neutrophile iyo lymphocyte of spearmint oil 100 mg x kg(-1) iyo kooxda dexamethasone ayaa si weyn hoos loogu dhigay, metaplasia unugga goblet ayaa sidoo kale la joojiyay.Dexamethasone waxay saameyn ku yeelatay muujinta TNF-alpha, IL-1beta, TIMP-1 iyo MMP-9.Saliida Spearmint 30, 100 mg x kg (-1) waxay si weyn hoos ugu dhigtay TNF-alpha iyo IL-1beta siday u kala horreeyaan.Saliida Spearmint 10, 30 iyo 100 mg x kg (-1) wax saameyn ah kuma yeelan muujinta TIMP-1, laakiin waxay hoos u dhigi kartaa muujinta MMP-9 si weyn oo loogu talagalay unugyada sambabada. maadaama ay wanaajiso burburka alveolar, caabuqa sambabada, iyo metaplasia unugga goblet.Habka waxaa ku jiri kara dhimista TNF-alpha, IL-1beta content iyo ka hortagga xad-dhaafka ah ee matrix metalloproteinase-9 ee unugyada sambabada.