Streptozocin CAS: 18883-66-4 budo crystalline jaale cirro leh
Lambarka buugaagta | XD90359 |
Magaca Alaabta | streptozocin |
CAS | 18883-66-4 |
Qaanuunka molecular | C8H15N3O7 |
Miisaanka Molecular | 265.22 |
Faahfaahinta Kaydinta | -20 °C |
Xeerka Tarifka La Iswaafajiyay | 29419090 |
Tilmaamaha Alaabta
Qiimayn | 99% |
Muuqashada | budo crystalline jaale cirro leh |
Sonkorowga mellitus waxay la xiriirtaa bararka heerka hoose ee joogtada ah iyo walbahaarka oksaydhka.Bupleurum Polysaccharides (BPs), oo ka go'doon Bupleurum smithii var.parvifolium waxay leedahay sifooyin anti-bararka iyo anti-oxidative.Si kastaba ha ahaatee, wax yar ayaa laga og yahay saameyntiisa daawaynta ee sonkorowga.Tijaabadan, saamaynta BP-yada ee yaraynta xanuunka macaanka iyo hababka hoose ayaa la baadhay.Qaabka jiirarka macaanka waxaa lagu aasaasay irbado intraperitoneal oo isdaba joog ah oo streptozotocin ah (100 mg/kg miisaanka jirka) muddo laba maalmood ah.Jiirarka leh heerarka gulukoosta dhiigga ee ka sarreeya 16.8mmol/L ayaa loo doortay tijaabooyin.Jiirarka sonkorowga qaba ayaa afka laga maamulay BPs (30 iyo 60 mg/kg) hal mar maalintii muddo 35 maalmood ah.BP-yadu ma aha oo kaliya inay si weyn hoos ugu dhacaan heerarka gulukooska dhiigga, laakiin sidoo kale waxay kordhiyeen kuwa insulin-ta serum iyo glycogen beerka ee jiirarka sokorowga marka loo eego jiirarka moodada.Intaa waxaa dheer, maamulka BPs waxay wanaajisay muujinta insulinta waxayna xakamaysay apoptosis ee xameetida jiirarka sokorowga.Indho-indheynta Histopathological waxay si dheeraad ah u muujisay in BP-yadu ay ka ilaaliyeen beeryarada iyo beeryarada waxyeellada oksaydhka iyo bararka.Natiijooyinkani waxay soo jeedinayaan in BP-yadu ay ilaaliyaan unugyada β-pancreatic iyo hepatocytes beerka iyo hagaajinta sonkorowga, kaas oo la xidhiidha sifooyinka anti-oxidative iyo anti-bararka.