Alaabta

(S)-(2-Chloro-5-iodophenyl) (4- (tetrahydrofuran-3-yloxy) phenyl) methanone, oo sidoo kale loo yaqaan CF3-112, waa xarun kiimiko ah oo leh dhowr codsi oo muhiim ah oo ku saabsan kiimikada daawada iyo daroogada horumarinta.Mid ka mid ah isticmaalka weyn ee CF3-112 waa sida kinase inhibitor ah.Kinases waa enzymes nidaamiya hababka kala duwan ee unugyada jirka, oo ay ku jiraan koritaanka unugyada, qaybinta, iyo isgaarsiinta.Habacsanaanta kinase waxaa inta badan lala xiriiriyaa cudurrada sida kansarka iyo cilladaha difaaca jirka.CF3-112 ayaa la ogaaday in ay soo bandhigto waxqabadyo awood leh oo ka hortagaya kinases gaar ah, taas oo ka dhigaysa musharrax rajo leh oo loogu talagalay horumarinta daaweynta la beegsanayo. inta badan aad bay ugu badan yihiin unugyada kansarka.Iyadoo la dooranayo oo la xakameynayo kinases-kan, CF3-112 ayaa laga yaabaa inay gacan ka geysato joojinta faafitaanka degdega ah ee unugyada kansarka waxayna suurtogal u tahay inay bixiso faa'iido daaweyneed. Intaa waxaa dheer, CF3-112 waxay muujisay waxqabad ka dhan ah kinases kale sida FLT3 iyo JAK2, kuwaas oo ku lug leh hematological. malignancies sida acute myeloid leukemia (AML) iyo neoplasms myeloproliferative.Joojinta kinase-yadan leh CF3-112 waxay awood u leedahay inay carqaladeyso dariiqyada calaamadaha ee keena koritaanka iyo badbaadada unugyada kansarka, iyagoo siinaya fursado cusub oo loogu talagalay daaweynta cudurradan. -saamaynta bararka.Caabuqa waa jawaab-celin bayooloji ah oo kakan oo door ka ciyaara cudurro badan, oo ay ku jiraan cilladaha difaaca jirka iyo xaaladaha bararka dabadheeraad ah.CF3-112 waxay muujisay ballanqaad sida xannibaadaha waddooyinka bararka qaarkood, oo laga yaabo inay bixiyaan hab daaweyn ah oo lagu maareynayo xaaladahan. Iyadoo CF3-112 ay haysato awood weyn, waxaa xusid mudan in cilmi-baaris dheeraad ah iyo horumarin loo baahan yahay si loo fahmo waxtarkeeda, badbaadada. profile, iyo codsiga ugu fiican.Sida xarun kasta, baaritaan adag iyo daraasado sax ah ayaa loo baahan yahay ka hor inta aysan u gudbi karin tijaabooyinka bukaan-socodka ee bini'aadamka. Gebogebadii, CF3-112 waa xarun leh karti weyn oo ku saabsan kiimikada daawada.Dhaqdhaqaaqeeda xakamaynta kinase, gaar ahaan ka soo horjeeda Aurora kinases, FLT3, iyo JAK2, waxay u dhigeysaa musharrax suurtagal ah horumarinta daaweynta la beegsanayo ee kansarka iyo cudurrada dhiig-baxa.Waxyaabaha ka hortagga bararka waxay sidoo kale soo jeedinayaan codsiyada suurtagalka ah ee maaraynta xanuunka difaaca jirka iyo xaaladaha bararka dabadheeraad ah.Si kastaba ha ahaatee, cilmi-baaris dheeraad ah ayaa lagama maarmaan u ah in la furo awooddeeda daawaynta oo buuxda oo lagu qiimeeyo ammaankeeda iyo waxtarkeeda.