Alaabta

Hyperkalemia inta lagu jiro joojinta nidaamka renin-angiotensin-aldosterone (RAAS-I) waxay ka hortagi kartaa qiyaasta ugu fiican.Ikhtiyaarada daawaynta waxaa ka mid ah sodiyam polystyrene sulfonate potassium ku xidha resins, laakiin walaacyada badbaadada iyo waxtarka ayaa jira, oo ay ku jiraan necrosis colonic (CN).Waxyaalaha beddelka ah ayaa la darsay, laakiin kharashka-utility-ga lama qiyaasin. Waxaanu samaynay falanqaynta kharashka kharashka bukaan-socodka ≥ 18 sano jir helaya RAAS-I daba-dheeraaday, oo leh taariikh hyperkalemia ama cudur kelyo daba-dheer, oo loo qoray mid ka mid ah sodium polystyrene sulfonate. ama "daroogada X" oo ku xidhan resin for hyperkalemia raaga.Xogta ayaa laga helay suugaanta jirta.Waxaan isticmaalnay qaab go'aan qaadasho oo leh Monte Carlo falanqaynta dareenka macquulka ah, marka laga eego aragtida bixiyaha daryeelka caafimaadka iyo 12-bilood horraantii.Qiimaha waxa lagu qiyaasay dollarka Maraykanka.Waxtarka waxaa lagu cabiray sanado-nololeedka tayada-habboon (QALYs), iyo korodhka qiimaha waxtarka-waxtarka (ICERs) WTP) heerka ugu hooseeya ee $50,000/QALY.Markay ahayd $ 40.00 maalintiiba, daawadu X waxay gaadhay korodhka waxtarka qiimaha korodhka ah ee $26,088,369.00 QALY kasta oo la helo.Falanqaynta xasaasiga ah ee hal-jidka ah ayaa muujisay sodium polystyrene sulfonate si ay u noqoto ikhtiyaarka waxtarka leh ee dhacdooyinka CN ≤ 19.9%.Xaddidaadaha waxaa ka mid ah macluumaadka aan dhamaystirnayn ee natiijooyinka bukaan-socodka iyo la'aanta xog si toos ah loo barbardhigayo sodium polystyrene sulfonate iyo beddelka suurtagalka ah. Ikhtiyaarada waxaa laga yaabaa inaysan noqon kuwo kharash-ool ah ilaa lagu qiimeeyo si la mid ah sodium polystyrene sulfonate.Falanqayntan waxay hagi kartaa go'aannada ku saabsan qaadashada wakiillo kale oo loogu talagalay xakamaynta hyperkalemia daba-dheer, waxayna soo jeedinaysaa in sodium polystyrene sulfonate loo isticmaalo sidii kontorool firfircoon ee tijaabooyinka bukaan-socodka ee wakiiladan.