Alaabta

Ku celcelinta kinase 2 (LRRK2) ee eucine-ka hodanka ah waa sababta ugu badan ee la og yahay ee cudurka Parkinson (PD).Astaamaha kiliinikada ee LRRK2 PD waa kuwo aan laga sooci karin idiopathic PD, oo leh ururinta α-synuclein iyo/ama tau iyo/ama ubiquitin ee isku-darka intraneuronal.Tani waxay soo jeedinaysaa in LRRK2 ay fure u tahay fahamka aetiology ee xanuunka.Inkasta oo shaqada luminta aysan u muuqan habka PD ee bukaannada LRRK2, ma cadda sida borotiinkani u dhexdhexaadiyo sunta.Daraasaddan, waxaan ku soo warramaynaa in LRRK2 xad-dhaafka ah ee unugyada iyo in vivo ay wax u dhimayso dhaqdhaqaaqa jidka ubiquitin-proteasome, iyo in tani ay xisaabinayso ururinta substrates kala duwan oo leh LRRK2 xad-dhaaf ah.Waxaan tusineynaa in tani aysan dhexdhexaadineynin isku-darka LRRK2 ee waaweyn ama kala soocida ubiquitin ee isku-darka.Muhiimad ahaan, cilladaha noocan oo kale ah laguma arko si xad dhaaf ah borotiinka la xidhiidha LRRK1.Xogtayadu waxay soo jeedinaysaa in LRRK2 ay joojiso nadiifinta substrate-ka borotiinka ee kor u kaca dhaqdhaqaaqa proteasome katalytic, iyada oo door bideysa ururinta borotiinnada iyo samaynta isku-darka.Markaa, waxaanu bixinaa isku xidhka molecular ee u dhexeeya LRRK2, sababta ugu badan ee loo yaqaan PD, iyo nooceeda hore ee lagu sharaxay ee ururinta borotiinka.