Alaabta

Joojinta β-carbonic anhydrases (CAs, EC 4.2.1.1) ee fangaska pathogenic Cryptococcus neoformans (Can2) iyo Candida albicans (Nce103) oo leh taxane 25 ah oo aliphatic ah iyo carboxylates caraf udgoon ayaa la baaray.isoforms aadanaha hCA I iyo II ayaa sidoo kale lagu daray daraasadda si loo barbardhigo.Carboxylates Aliphatic guud ahaan waxay ahaayeen millimolar hCA I iyo II inhibitors iyo micromolar/submicromolar β-CA inhibitors hoose.Carboxylates caraf udgoon waxay ahaayeen micromolar inhibitors ee afarta enzymes laakiin qaar ka mid ah ayaa muujiyay waxqabadyo nanomolar hooseeya oo ka dhan ah enzymes pathogenic fungal.4-Hydroxy- iyo 4-methoxy-benzoate waxay joojiyeen Can2 oo leh K(I) s 9.5-9.9 nM.The methyl esters, hydroxamates, hydrazides iyo karboksamides ee qaar ka mid ah derivatives ayaa sidoo kale ahaa hor joogayaasha waxtar leh ee α- iyo β-CAs ayaa lagu baaray halkan.

Parabens-ku waxay ka mid yihiin waxyaalaha ilaaliyayaasha inta badan la isticmaalo si loo xakameeyo korriinka microbial-ka loona kordhiyo nolosha shelf ee badeecadaha kala duwan ee macaamiisha.Ujeedada daraasadda hadda jirta waxay ahayd in la helo aragti ku saabsan dheef-shiid kiimikaadka parabens ee unugyada kansarka naasaha (MCF7) tan iyo markii ay muujiyeen dhaqdhaqaaqa estrogenic ee unugyadan waxaana laga helay unugyada kansarka naasaha.Sunta parabens-ka ee unugyada MCF7 waxaa lagu go'aamiyay iyadoo la isticmaalayo imtixaannada MTT.Hydrolysis of methyl-, butyl iyo benzyl-paraben ilaa p-hydroxybenzoic acid ayaa lagu falanqeeyay unugyada dhaqanka ee MCF7 iyo in homogenates gacanta.Glucuronidation iyo sulfoconjugation ayaa lagu bartay MCF7 homogenates, iyo parabens waxaa falanqeeyay HPLC.Methyl-paraben ayaa la muujiyay in uu aad uga yar yahay sunta butyl iyo benzyl-paraben.Parabens waxay si buuxda u degganaayeen MCF7 homogenates halka p-nitrophenyl acetate, nooc substrate ah, lagu sameeyay hydrolysis.homogenates unug MCF7 ma muujin glucuronidation iyo sulfoconjugation hawlaha parabens.Xasiloonida sare ee parabens-ka ayaa laga yaabaa inay sharaxdo ururkooda kansarka naasaha.