N- (2-Acetamide) iminodiacetic acid Cas: 26239-55-4 99% budada cad
| Lambarka buugaagta | XD90194 |
| Magaca Alaabta | ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Qaanuunka molecular | C6H10N2O5 |
| Miisaanka Molecular | 190.15 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 29241900 |
Tilmaamaha Alaabta
| Fe | <5pm |
| Pb | <5pm |
| Khasaare xagga qallajinta | <0.5% |
| Dambaska sulfated | <0.1% |
| Muuqashada | budo cad |
| Xalka Kale | Midna |
| Waqtiga Kala dirida (9g gudaha 91ml 1M NaOH, Kicinta Magnetic) | <1 daq |
| A300 (9% gudaha 1 M NaOH) | <0.08% |
| Tirada dhibcaha dhamaadka lagu arkay qalooca titration | Laba kaliya |
| Range pH kaas oo qeexaya Titration barta dhamaadka labaad | 9.1 - 10.1 |
| Solubility (9% 1M NaOH) | Cad oo aan midab lahayn |
| Taariikhda wax-soo-saarka | |
| Biyaha KF | <1% |
| Assay (Titration) oo ku salaysan qalalan | >99.0% |
| Infrared | U hogaansama |
Adenosine-ka nucleoside wuxuu ku shaqeeyaa habdhiska dareenka iyo wadnaha iyada oo loo marayo soo-dhoweynta A2A (A2AR).Iyada oo laga jawaabayo heerka ogsijiinta ee unugyada, xoojinta plasma adenosine ayaa si gaar ah loogu habeeyaa iyada oo la adeegsanayo CD73 iyo iyada oo loo marayo hoos u dhigida adenosine deaminase (ADA).Unugyada dusha sare ee endopeptidase CD26 waxay xakameysaa uruurinta peptides-ka vasoactive iyo antioxidant-ka oo markaa nidaamiya sahayda oksijiinta ee unugyada iyo jawaab celinta oksijiinta.Inkasta oo xad-dhaafka ah ee adenosine, CD73, ADA, A2AR, iyo CD26 ee ka jawaabaya hypoxia si fiican loo diiwaangeliyay, saameynta hyperoxic iyo hyperbaric ee walxahan waxay mudan yihiin tixgelin dheeraad ah.Jiirka iyo xariiqda unugga murine ee Chem-3 ee qeexaya A2AR ayaa la soo bandhigay 0.21 bar O2, 0.79 bar N2 (xaalad dhulka; normoxia);1 bar O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 bar O2, 1.79 bar N2 (hyperbaria).Fiirinta balaasmaha Adenosine, CD73, ADA, A2AR muujinta, iyo waxqabadka CD26 ayaa looga hadlay vivo, iyo wax soo saarka cAMP waxaa looga hadlay cellulo.Xaaladaha vivo, 1) hyperoxia waxay hoos u dhigtay heerka adenosine plasma heerka iyo T unugga dusha CD26, halka ay kordhisay muujinta CD73 iyo heerka ADA;2) hyperbaric hyperoxia waxay u janjeertay inay kordhiso isbeddelka;iyo 3) hyperbaria oo keliya ayaa ka maqan saamayn weyn oo ku saabsan xuduudahan.Maskaxda iyo cellulo, 1) hyperoxia waxay hoos u dhigtay muujinta A2AR;2) hyperbaric hyperoxia waxay xoojisay isbeddelka;iyo 3) hyperbaria oo keliya ayaa muujisay saameynta ugu xooggan.Waxaan helnay qaab la mid ah oo ku saabsan labadaba isku-dhafka A2AR mRNA ee maskaxda iyo wax soo saarka cAMP ee unugyada Chem-3.Markaa heerka ogsijiinta sare waxay u janjeertay inay hoos u dhigto dariiqa adenosinergic iyo dhaqdhaqaaqa CD26.Hyperbaria kaligeed waxay saamaysay kaliya muujinta A2AR iyo wax soo saarka cAMP.Waxaan ka wada hadlaynaa sida hababkan oo kale ay kiciyaan hyperoxygenation ay u xaddidi karaan, iyada oo loo marayo vasoconstriction, sahayda oksijiinta unugyada iyo soo saarida noocyada ogsijiinta falcelinta.
