Alaabta

Eu (dpq) (DMF) 2 (NO3) 3] (1), [Eu (dppz) 2 (NO3) 3] (2), Tb (dpq) iyo terbium (III) (DMF) 2Cl3] (3), iyo [Tb (dppz) (DMF) 2Cl3] (4), halka dipyrido [3,2-d:2',3'-f] quinoxaline (dpq ee 1 iyo 3) , dipyrido [3,2-a: 2',3'-c] phenazine (dppz in 2 iyo 4) iyo N, N'-dimethylformamide (DMF) ayaa la go'doomiyey, oo lagu gartaa xogta physicochemical, daraasadaha iftiinka iyo isdhexgalka. oo leh DNA, borotiinka serum albumin iyo waxqabadyada kala-goynta DNA ee sawir-qaadista ayaa la daraaseeyaa.Qaab dhismeedka kristal raajada ee ka kooban 1-4 waxay muujinayaan qaabdhismeedka mononuclear-ka Ln(3+) ku salaysan.Eu (3+) ee ku jira [Eu (dpq) (DMF) 2 (NO3) 3] (1) iyo [Eu (dppz) 2 (NO3) 3] (2) sida [Eu (dpq) (NO3) ] · dppz (2a) waxay qabataa qaab dhismeedka dodecahedron toban isku-dubbarid leh oo leh N,N-deeq-bixiye dpq ligand, laba DMF iyo saddex NO3 (-) anions ee 1 iyo laba bidentate N, N-deeqaha dppz ligands iyo saddex NO3 ( -) anions ee 2. Complexes 3 iyo 4 waxay muujinayaan qaab dhismeedka octahedron-ka-kooban ee todoba-isku-dubbariday halkaasoo Tb(3+) ay ka kooban tahay bidentate dpq/dppz ligands, laba DMF iyo saddex Cl(-) anions.Dhismayaashu waa kuwo aad u iftiimaya oo dabeecad ahaan muujinaya wareejinta tamar hufan ee sawir-qaadka leh ee dpq/dppz ilaa Ln(3+) si ay u abuurto xaalado xiiso leh oo cimri dheer oo loogu talagalay sifada f → f kala-guurka.Muuqaalka iftiinka wakhtiga la xaliyay ee dhismayaasha 1-4 waxay muujinayaan xadhkaha qiiqa qiiqa caadiga ah ee loo aanaynayo (5)D0 → (7)F(J) iyo (5)D4 → (7)F(J) ff wareejinta Eu(3) +) iyo Tb (3+) siday u kala horreeyaan.Tirada unugyada biyaha gudaha-sphere (q) waxaa lagu go'aamiyay cabbiraadaha cimriga luminescence ee H2O iyo D2O taasoo xaqiijinaysa falcelinta ligand-isweydaarsiga biyaha ee xalka.Dhismayaashu waxay muujinayaan ku-xidhnaan la taaban karo oo CT-DNA ah oo siinaya qiyam joogto ah oo ku xidhan inta u dhaxaysa 1.0 × 10 (4) -6.1 × 10 (4) M (-1) siday u kala horreeyaan 2, 4 (dppz)> 1, 3 (dpq)Xogta ku xidhan DNA waxay soo jeedinaysaa jeexdin DNA-da oo ku xidhan dabeecadda isku xidhka qaybeed ee dhismayaasha.Dhammaan dhismayaashu waxay sidoo kale muujinayaan u janjeersiga xidhitaanka (K(BSA) ~ 10(5) M(-1)) borotiinka serum albumin (BSA).Xoojinta xadhkaha iftiinka iftiinka ee wakhtiga-gated ayaa si weyn kor ugu qaadaya xoojinta DNA-da ee sii kordheysa ee dhexdhexaadiyaha aqueous sababtoo ah barokaca biyaha xidhxidhan ee la falgalka DNA-da, sidaas awgeed hoos u dhigista shucaaca aan shucaaca ahayn ee OH oscillator.Isku-dhafka 1-4 waxay si hufan ugu dhejiyaan supercoiled (SC) ds-DNA si ay u sameeyaan wareeggeeda niiqsan (NC) qaabka soo-gaadhista UV-A iftiinka 365 nm iyada oo loo marayo samaynta oksijiinta hal-abuurka ah ((1) O2) iyo hydroxyl radicals (HO˙) sida noocyada ogsijiinta fal-celiska ah ee fiirsashada micromolar ee xaaladaha jireed.