Alaabta

Khatarta iska caabbinta microbial-ka oo ay weheliso la'aanta antimicrobials cusub ayaa kor u kacday xiisaha horumarinta peptides antimicrobial (AMPs) sida daaweynta cusub.Daraasaddan, waxaan ku qiimeynay hawlaha ka hortagga jeermiska ee laba peptides synthetic gaagaaban, kuwaas oo kala ah, RRIKA iyo RR.peptides-yadani waxay soo bandhigeen firfircoonida antimicrobial awood leh oo ka dhan ah Staphylococcus aureus, iyo saameyntooda antimicrobial ayaa si weyn loo wanaajiyey iyada oo lagu daray saddex amino acids oo ku jira terminus C, taas oo markaa kordhisay amphipathicity, hydrophobicity, iyo kharashka saafiga ah.Waxaa intaa dheer, RRIKA iyo RR waxay muujiyeen saameyn bakteeriyo ah oo weyn oo degdeg ah oo ka dhan ah kiliinikada iyo daawada u adkaysata Staphylococcus, oo ay ku jiraan Staphylococcus aureus (MRSA), vancomycin-dhexdhexaadiyaha S. aureus (VISA), vancomycin u adkaysta S. aureus (VRSA) , S. aureus u adkaysta linezolid, iyo Staphylococcus epidermidis u adkaysta methicillin.Si ka duwan AMP-yada dabiiciga ah ee badan, RRIKA iyo RR waxay sii haysteen t dhaqdhaqaaqa dhaxalka iyadoo ay joogaan xaddiyada jireed ee NaCl iyo MgCl2.RRIKA iyo RR labaduba waxay xoojiyeen dilka lysostaphin in ka badan 1,000-laab waxayna tirtireen go'doominta MRSA iyo VRSA 20 daqiiqo gudahood.Intaa waxaa dheer, peptides-ka la soo bandhigay waxay ahaayeen kuwo aad u sarreeya si loo yareeyo biofilms-ka ee S. aureus iyo S. epidermidis marka la barbardhigo natiijooyinka antibiyootiga caadiga ah.Natiijooyinkayagu waxay muujinayaan in saamaynta staphylocidal ee peptides-kayadu ay ahaayeen iyada oo la sii daayay xuubabka bakteeriyada, taasoo horseedaysa daadinta waxa ku jira cytoplasmic iyo dhimashada unugyada.Intaa waxaa dheer, peptides ma ahayn kuwo ku suntan unugyada HeLa ee 4- ilaa 8-laab uruurintooda antimicrobial.Dhaqdhaqaaqyada antimicrobial ee xoogga leh iyo milix-la'aanta ah ee peptides-kan ayaa soo bandhigaya musharax daaweyn soo jiidasho leh oo loogu talagalay daaweynta cudurrada S. aureus u adkaysta daawooyinka badan.