L-Tryptophan Cas: 73-22-3 99% budo cad
| Lambarka buugaagta | XD90295 |
| Magaca Alaabta | L-Tryptophan |
| CAS | 73-22-3 |
| Qaanuunka molecular | C11H12N2O2 |
| Miisaanka Molecular | 204.22518 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 29339980 |
Tilmaamaha Alaabta
| Qiimayn | 99% min |
| Muuqashada | budo cad |
| Darajo | USP32 |
| Wareegid gaar ah | -29.4 ilaa -32.8 |
| pH | 5.5 ilaa 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Khasaare xagga qallajinta | <0.3% |
| Hadhaaga dabka | 0.1% ugu badnaan |
| Cl | 0.05% ugu badnaan |
Indoleamine 2,3-dioxygenase (IDO1) iyo tryptophan 2,3-dioxygenase (TDO) waa laba qaab dhismeed oo kala duwan oo leh qaybinta unugyada kala duwan iyo doorarka jireed, laakiin labaduba waxay kicinayaan beddelka tryptophan ee N-formylkynurenine (NFK).IDO1 ayaa si kiliinig ah loo ansixiyay inay tahay bartilmaameedka daawada-molecule-yar ee kansarka, halka daraasaadka saxda ah ay muujinayaan in TDO laga yaabo inay bartilmaameed u tahay kansarka immunotherapy iyo cudurka neurodegenerative.Waxaan u samaynay qiimayn heersare ah oo baadhiseed oo loogu talagalay IDO1 iyo TDO oo ku salaysan baadhitaan kiimiko oo cusub, NFK Green, oo si gaar ah ula falgasha NFK si ay u sameeyaan unug-fluorescent molecule oo cagaar ah oo leh mowjad xamaasad leh oo ah 400 nm iyo hirarka qiiqa ee 510 nm.Waxaan bixinaa isbarbardhigga ugu horreeya ee isbarbardhigga tiro ka mid ah xannibiyeyaasha la daabacay ee IDO1 iyo TDO waxaanan daaha ka qaadaynaa in IDO1 inhibitor Compound 5l ay muujinayso falcelin muhiim ah oo TDO ah, halka xulashada qaraabada ee horjoogayaasha kale ee la daabacay la xaqiijiyay.Ku habboonaanta baadhista-sare ee baadhista waxa lagu muujiyey baadhista maktabad ka kooban 87,000 walxood oo kiimiko ah oo qaabaysan 384 ama 1536Ugu dambeyntii, waxaan muujineynaa in baaritaanka sidoo kale loo isticmaali karo in lagu cabbiro awoodda unugyada si ay u metaboolaan tryptophan iyo in la cabbiro awoodda gacanta ee IDO1 iyo TDO inhibitors.
