Alaabta

Islet amyloid polypeptide (IAPP; sidoo kale loo yaqaan amylin) ayaa mas'uul ka ah samaynta islet amyloid ee nooca 2-aad ee sonkorowga, iyo sunta IAPP-ku keentay ayaa la rumeysan yahay inay gacan ka geysato luminta tirada unugyada β-unugyada ee la xidhiidha marxaladaha dambe ee nooca 2aad ee sonkorowga.Samaynta amyloid ee Islet ayaa sidoo kale laga yaabaa inay door ka ciyaarto fashilka tallaalka ka dib tallaalka.IAPP waxaa loo soo saaraa prohormone ahaan, pro-islet amyloid polypeptide (proIAPP), waxaana lagu farsameeyaa granuls-ka sirta ah ee unugyada β-gamaca.Noocyada qayb ahaan la farsameeyay ee proIAPP waxa laga helaa kaydadka amyloid;Waxa ugu caansan waa 48-hadha dhexdhexaad ah, proIAPP(1-48), oo ay ku jirto N-terminal pro-extension, laakiin si sax ah looga shaqeeyay C-terminus.Habaynta aan dhamaystirnayn ayaa laga yaabaa inay door ka ciyaarto samaynta amyloid ee islet iyadoo kor u qaadaysa isdhexgalka proteoglycans sulfated ee matrixka unugyada ka baxsan, taas oo, iyaduna, kor u qaadaysa samaynta amyloid.Waxaan tusineynaa fuchsin acid (3- (1--amino-3-methyl-5-sulphonatophenyl) -1- (4-amino-3-sulphonatophenyl) methylene) cyclohexa-1,4-dienesulphonic acid), fudud sulfonated triphenyl methyl derivative, waa horjooge awood leh ee samaynta amyloid ee proIAPP(1-48) dhexe.Trifenyl methane derivative aadka u adag ee FCF cagaarka ah {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino] phenyl [4-hydroxy-2-sulfophenyl) methylidene] -1-cyclohexa -2,5-dienylidene] -[(3-sulfophenyl)methyl]azanium} sidoo kale waxay joojisaa samaynta amyloid ee IAPP iyo dhexdhexaadinta proIAPP.Labada xeryoodba waxay xakameeyaan samaynta amyloid iyagoo isku darsamaya dhexdhexaadiyaha proIAPP iyo nooca glycosaminoglycan heparan sulfate.Acid fuchsin waxay sidoo kale joojisaa samaynta amyloid-ku-dhexdhexaadinta glycosaminoglycan iyadoo loo marayo IAPP qaan-gaar ah.Awoodda lagu joojinayo samaynta amyloid maaha mid fudud sababtoo ah xeryahooda sulfonated, tan iyo sulfonated inhibitor ee amyloid-β, tramiprosate, ma aha xannibaadaha samaynta amyloid by proIAPP (1-48).