Cagaar degdeg ah: 2353-45-9 Casaan ilaa budo bunni ah
| Lambarka buugaagta | XD90527 |
| Magaca Alaabta | Cagaar degdeg ah |
| CAS | 2353-45-9 |
| Qaanuunka molecular | C37H34N2Na2O10S3 |
| Miisaanka Molecular | 808.85 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 32129000 |
Tilmaamaha Alaabta
| Muuqashada | Casaan ilaa budo |
| Qiimayn | ≥99% |
| Walaxda aan biyuhu milmin | ≤0.20% |
Caabuqa marin-haweedka daba-dheeraada iyo dib-u-habaynta, oo ay ku jiraan fibrosis, ayaa loo soo jeediyay inay yihiin wax-ka-qaatayaal muhiim ah oo ka qaybqaata cudurrada neefta.Daraasadihii hore ee fibrosis-ka hawo-mareenka ayaa inta badan lagu sameeyay xiiq fudud iyo dhexdhexaad ah heerka "xuubka hoose" (SBM).Daraasadda hadda jirta waxaa loogu talagalay in lagu qiimeeyo marin-haweedka weyn ee SBM dhumucda iyo kaydinta kolajka submucosal, sida lagu cabbiray saddex hababka midabaynta kolajka ee kala duwan, xuubka endobronchial ee 17 daran, sagaal dhexdhexaad ah, iyo todoba neef oo fudud, iyo sidoo kale siddeed maaddo oo caadi ah.Unugyada eosinophils iyo beddelidda factor factor-beta (TGF-beta) immunoreactivity ayaa sidoo kale la baaray.Ma jirin kala duwanaansho la taaban karo oo ku saabsan dhumucda SBM, kaydinta kolajka submucosal, lambarada eosinophils, ama unugyada togan ee TGF-beta ee ka mid ah saddexda kooxood ee neefta iyo maadooyinka xakamaynta caadiga ah.Waxay ahayd kaliya markii la baaray dhammaan neefta (n = 33) wadajir, in SBM oo dhumuc yar leh (p = 0.04), sida lagu qiimeeyay kolajka nooca III immunostaining, ayaa la arkay marka la barbar dhigo maaddooyinka kantaroolka caadiga ah.Inkasta oo kala duwanaanshiyahan, wax farqi weyn ah looma helin qaddarka hoos u dhigista kolajka submucosal iyo tirada eosinophils ama unugyada TGF-beta marka la barbardhigo wadarta neefta iyo maadooyinka caadiga ah ee kantaroolka.Intaa waxaa dheer, wax xiriir ah oo la taaban karo lagama helin inta u dhaxaysa kaydinta kolajka iyo tirinta eosinophils, heerka muujinta TGF-beta, FEV1, ama muddada neefta.Natiijooyinkani waxay soo jeedinayaan in inkasta oo korodhka kaydinta kolajka ee SBM ee heerka marin-haweedka weyn ay tahay sifada neefta, laga yaabo inaysan sharaxin kala duwanaanshaha darnaanta neefta.
