Doxorubicin hydrochloride CAS: 25316-40-9 99% budada Crystalline-cas Orange-cas
| Lambarka buugaagta | XD90367 |
| Magaca Alaabta | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Qaanuunka molecular | C27H29NO11·HCl |
| Miisaanka Molecular | 579.98 |
| Faahfaahinta Kaydinta | 2 ilaa 8 °C |
| Xeerka Tarifka La Iswaafajiyay | 29419000 |
Tilmaamaha Alaabta
| BiyoNuxurka | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Ku milmay: biyaha, methanol iyo isotonic NaCl(aq).Soluble liidata ee chloroform iyo dareerayaasha kale ee organic. |
| Walxaha laxidhiidha | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Qiimayn | 99% |
| Xalalka Haraaga ah | Acetone iyo khamriga: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Wax kasta oo wasakh kale ah | ≤ 0.5% |
| Wadarta wasakhda | ≤ 2.0% |
| Crystallinity | U hogaansama USP |
| Muuqashada | Budada Crystalline-cas |
| Aqoonsiga | HPLC |
Bukaannada qaba P-glycoprotein iyo HER2/neu (HER2) reseptor-ka-soo-baxa kansarka naasaha badanaa waxay leeyihiin natiijooyin caafimaad oo liita.Si kastaba ha ahaatee, ma jiraan khadadka unugyada kansarka naasaha oo ganacsi ahaan loo heli karo kuwaas oo ah HER2/P-glycoprotein double-positive, taas oo xaddidaysa cilmi-baarista goobtan. Waxaan ka warbixineynaa horumarinta iyo sifada xariiq-hoosaadka u adkeysiga daawada ee naaska HER2-positive Khadka unugyada kansarka by wareejinta xasilloon ee cajaladda ATP-binding (ABC) ee xubinta qoyska B 1 (ABCB1) hiddo-wadaha kaas oo qeexaya P-glycoprotein.ABCB1 heerarka muujinta hidda-wadaha ayaa sare u kacay ka dib gudbinta, taas oo horseeday koror 40-laab ah P-glycoprotein muujin.Waxa xiiso leh, gudbinta ABCB1 waxay sidoo kale keentay koror yar oo ah hiddo-wadaha HER2 iyo heerarka muujinta borotiinka.Gudbinta ABCB1 waxay kordhisay heerarka muujinta P-glycoprotein si aad ah. Habka loo isticmaalo halkan si loo horumariyo xariiqda unuggu waxay ku habboon tahay si degdeg ah, oo xasilan oo loogu talagalay caabbinta daawada P-glycoprotein dhexdhexaadinta marka la barbar dhigo hababka aditional tr.Tijaabada cytotoxicity in vitro waxay soo jeedinaysaa in xariiqda unuggu leeyahay iska caabin badan oo kala duwan oo ah kiimiko-dabiiciga ah.
