Alaabta

Dhiig-baxa xididdada dhiigga ayaa gacan ka geysta cudurrada caabuqa.Hababka hadda jira ee qiimaynta in vivo ee ku-meel-gaadhka ah ee ku salaysan xad-dhaafka ah ee Evans Blue (EB) -ku xidhan albumin waa dhib badan oo inta badan aan lahayn dareen.Waxaan soo saarnay hab cusub oo loo yaqaan 'infrared fluorescence' (IRF) oo loogu talagalay cabbiraadda EB-albumin-ka dheeraadka ah si loo qiyaaso qulqulka xididdada dhiigga ee moodooyinka murineka.Dareemidda xididdada dhiigga ee ay keento endotoxemia ayaa lagu baadhay dhammaan xubnaha adag, maskaxda, maqaarka iyo peritoneumka IRF iyo cabbirka nuugista-dhaqameed ee EB ee soosaarka unugyada.Xubinta IRF ayaa si toos ah u korodhay iyada oo la kordhinayo uruurinta EB xididada (2.5-25 mg/kg).Unugyada IRF waxay aad ugu nugul yihiin ururinta EB marka la barbar dhigo habka ku salaysan nuugista.Sidaa awgeed, kala duwanaanshaha xididdada xididdada dhiigga iyo ururinta xubnaha EB ee u dhexeeya lipopolysaccharide-la daweeyay iyo jiirarka salineed ee cusbada lagu daaweeyay ayaa inta badan ahaa mid muhiim ah marka la falanqeeyo ogaanshaha ku salaysan IRF laakiin ma aha ogaanshaha ku salaysan nuugista.EB waxaa laga helay dhammaan xubnaha 353 ee lagu falanqeeyay IRF laakiin kaliya 67% (239/353) ee xubnaha ayaa lagu falanqeeyay habka ku saleysan nuugista, taasoo muujineysa dareenka soo hagaagay ee ogaanshaha EB ee xubnaha leh IRF.Taas bedelkeeda, EB ee balasmaha ka dib maamulka EB si sahal ah ayaa loo cabbiray labada hab oo leh xiriir sare oo u dhexeeya labada hab (n=116, r2=0.86).Tirada xubnaha gaarka ah ee EB-IRF kala duwanaanshiyaha endotoxin ayaa ugu fiicnaa markii IRF la barbar dhigo jiirarka u dhigma miisaanka, jinsiga, iyo da'da, iyo sixitaanka ku habboon miisaanka xubnaha iyo fiirsashada balasmaha EB.Gaar ahaan, habka EB-IRF wuxuu ka tagayaa xubnaha si sax ah loogu talagalay histopathology xiga.Marka la soo koobo, EB-IRF waa sheeko cusub, aad xasaasi u ah, degdeg ah, iyo hab ku habboon cabbirka qaraabada EB ee xubnaha daawaynta oo ka soo horjeeda jiirka.