Alaabta

Suugaanta soo baxday waxay soo jeedinaysaa in bisphenol A (BPA), oo ah kiimiko carqaladeeya endocrine baahsan, marka soo-gaadhista ay dhacdo nolosha hore, ay kordhin karto halista cudurka dheef-shiid kiimikaadka.Daraasaddan, waxaan ku baarnay mala-awaalka ah in soo-gaadhista dhalmada ee BPA ay u horseeddo farcanka cudurka beerka dufanka leh: muujinta cagaarshow ee cilladda dheef-shiid kiimikaadka, iyo habka suurtogalka ah.Jiirka Wistar uurka leh waxaa lagu maamulay BPA (40μg/kg/maalintii) ama baabuur inta lagu jiro uurka iyo nuujinta.Taariikhda beerka, falanqaynta biochemical, transcriptome, iyo shaqada mitochondrial ayaa lagu baadhay faraca labka ah ee dhalmada ka dib 3, 15 iyo 26 toddobaad.Isbuucyada 3 da'da, qaab-dhismeedka beerka ee aan caadiga ahayn iyo shaqada laguma arag farcanka soo shaac baxay BPA, laakiin hoos u dhac ku yimid dhaqdhaqaaqa neefsiga mitochondrial (MRC) (I iyo III) iyo isbeddello muhiim ah oo muujinta hidda-wadaha ee ku lug leh dheef-shiid kiimikaadka dufanka leh ee mitochondrial la arkay marka la barbar dhigo kontaroolada.Usbuucyada 15, steatosis micro-vesicular ee beerka, hiddo-wadaha kor u kaca ee ku lug leh dariiqyada lipogenesis, kororka jiilka ROS iyo sii deynta Cytc ayaa lagu arkay faraca BPA-soo bandhigay.Dabadeed, ururinta dufanka badan ee beerka iyo serum sare ee ALT ayaa lagu arkay faraca BPA-ga soo shaac baxay 26 toddobaad.Kormeerka dheer, shaqada mitochondrial hepatic oo ay ku jiraan waxqabadka MRC, wax soo saarka ATP, jiilka ROS iyo awoodda xuubabka mitochondrial ayaa si tartiib tartiib ah uga sii dartay faracyada BPA-ga.Soo-gaadhista Perinatal BPA waxay gacan ka geysataa horumarinta steatosis cagaarshow ee farcanka jiirka, kaas oo laga yaabo in lagu dhexdhexaadiyo iyada oo loo marayo shaqada mitochondrial hepatic ee daciifka ah iyo kor u qaadida dheef-shiid kiimikaadka beerka.