Alaabta

Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride waa iskudhis kiimiko ah oo ka hela codsiga goobta kimisteriga daawada iyo horumarinta daroogada.Qaab dhismeedka molecular wuxuu ka kooban yahay giraanta pyrrolidine oo leh koox tert-butyl ah oo ku taal booska cis, koox ethyl ah, iyo laba kooxood oo karboksilate ah.Xaruntan waxaa sida caadiga ah laga helaa qaabka cusbada hydrochloride. Mid ka mid ah isticmaalka ugu muhiimsan ee cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride waxay ku jirtaa isku-dhafka iyo horumarinta daawooyinka lagu beegsanayo bartamaha. habdhiska dareenka (CNS).Joogitaanka giraanta pyrrolidine, oo ay weheliso kooxaha tert-butyl iyo ethyl, waxay siisaa xaruntan leh sifooyinka neerfaha ee suurtagalka ah.Cilmi-baadhayaashu waxay u isticmaali karaan xaruntan sidii qalab bilow ah si ay u soo saaraan analoogyada ama soosaarayaasha kuwaas oo si xushmad leh ula falgali kara soo-qabayaal gaar ah ama enzymes ee CNS.Iyada oo wax laga beddelayo qaab-dhismeedka iyo beddelka, waxay wanaajin karaan guryaha farmashiyaha ee xarunta, waxay wanaajiyaan isku-xirnaanta soo-dhoweynta, oo wanaajiya awooddeeda daweynta. Intaa waxaa dheer, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride waxay noqon kartaa loo shaqaaleysiiyay sida qalab ka kooban daraasaadka bayooloji si loo baaro doorka receptors gaar ah ama enzymes ee hababka neerfaha.Adigoo isticmaalaya xaruntan sida ligand ama baaritaan, cilmi-baarayaashu waxay baran karaan isku xirnaanta isku xirnaanta, xulashada, iyo habka ficilka soo-dhoweynta ama enzymes-ka.Macluumaadkan ayaa muhiim u ah fahamka saldhigga molecular ee hababka neuropharmacological iyo horumarinta daweynta cusub ee lagu beegsanayo xanuunka neerfaha, xaaladaha maskaxda, ama cudurrada neerfaha. Xarunta ayaa sidoo kale leh codsiyo suurtagal ah oo ku saabsan helitaanka daroogada iyo baaritaanka sare ee baaritaanka.Waxaa lagu dari karaa maktabadaha xeryahooda, kuwaas oo laga baarayo bartilmaameedyo kala duwan, sida reseptors ama enzymes, si loo aqoonsado xeryahooda rasaasta ama musharaxiinta daroogada.Baadhitaankani wuxuu u oggolaanayaa in la aqoonsado xeryahooda soo bandhigaya sifooyinka dawooyinka ee la jecel yahay ama saamaynta daweynta ee suurtogalka ah.Intaa waxaa dheer, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ayaa laga yaabaa inay ka hesho waxtarka horumarinta daawooyinka.Daawooyinku waa xeryahooda aan firfircoonayn ama firfircoonayn kuwaas oo loogu talagalay in lagu dheefshiido qaabkooda firfircoon marka ay jidhka ku jiraan.Iyada oo wax laga beddelayo qaab-dhismeedka xaruntan, cilmi-baarayaashu waxay abuuri karaan foomamka dawooyinka kuwaas oo aad u deggan, hagaajiyay bioavailability, ama si fudud uga gudbi kara xuubka noolaha.Tani waxay kor u qaadi kartaa faa'iidooyinka daaweynta ee xarunta waxayna wanaajisaa sifooyinka farmashiyaha. Soo koobid, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride , sida qalab isku dhafan oo loogu talagalay daraasadaha bayoolojiga, helitaanka daroogada, iyo horumarinta daroogooyinka.Qaab dhismeedkeeda molecular ee gaarka ah waxa uu bixiyaa fursado wax ka beddelka iyo hagaajinta si kor loogu qaado astaamaheeda dawooyinka iyo hawlaha noolaha.Kala-duwanaanta iyo kartida xaruntan ayaa ka dhigaysa hanti muhiim ah oo ku taal berrinkii kimisteriga daawada iyo horumarinta daroogada.