![Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl) -methane Cas: 6976-37-0 99% Sawirka](http://cdn.globalso.com/xdbiochems/6976-37-0.jpg)
Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99%
| Lambarka buugaagta | XD90111 |
| Magaca Alaabta | BIS-TRIS (Bis (2-hydroxyethyl) amino-tris (hydroxymethyl) methane) |
| CAS | 6976-37-0 |
| Qaanuunka molecular | C8H20NO5 |
| Miisaanka Molecular | 210.2476 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 2922190090 |
Tilmaamaha Alaabta
| Biraha culus | <10ppm |
| Hadhaaga dabka | <0.1% |
| Pka | 6.3-6.7 |
| Muuqashada | Budada Crystalline White |
| Solubility (1M gudaha H20) | Cad oo dhamaystiran |
| pH (1M gudaha H2O) | 9.0-11.0 |
| Qoyaanka (LOD) | 1.0% ugu badnaan |
| Qiimaynta (Titration on qalalan) | 99.0% min. |
Buffer, oo loo isticmaalo ogaanshaha creatine-creatinase;sidoo kale loo isticmaalo ilaalinta waxtarka leh ee hemoglobin ee qalajinta qaboojinta;catholyte, oo loo isticmaalo IEF/2-D jel electrophoresis.
Glial cell line-derived neurotrophic factor (GDNF) waa horjooge awood leh ee isticmaalka ethanol iyo soo noqoshada, iyo GDNF heterozygous knockout jiirarka waxay muujinayaan abaal-marin kordhinta dareenka ethanol waxayna cunaan ethanol badan ka dib muddo ka fogaansho ah marka loo eego xayawaannada duurjoogta ah.Halkan, waxaan ku tijaabinay in ethanol uu wax ka beddelo muujinta GDNF ee aagga ventral tegmental (VTA; goobta GDNF ee ficilka) iyo / ama xudunta xudunta (NAc; isha ugu weyn ee GDNF), iyo haddii ay sidaas tahay, go'aami doorka korriinka koritaanka endogenous ee nidaamka isticmaalka ethanol.Maamulka nidaamka ethanol wuxuu kordhiyey muujinta GDNF iyo heerarka borotiinka ee VTA, laakiin maaha NAC.Intaa waxaa dheer, heerarka GDNF ayaa sare loo qaaday ka dib markii ethanol-cabitaanka fadhiga ee jiirka cunay ethanol ee habka xulashada laba dhalada ah ee dhexdhexaadka ah ee usbuuca 1, laakiin maaha 7 toddobaad.Hoos u dhigista ka dib toddobaadyada 7 ee qaadashada ethanol ee xad-dhaafka ah ayaa hoos u dhigtay heerarka GDNF, iyada oo muddo gaaban ethanol-ka cabbitaanka xad-dhaafka ah ka dib hoos u dhigista muujinta GDNF.Muhiimad ahaan, garaaca GDNF gudaha VTA iyadoo la adeegsanayo adenovirus oo muujinaya timo gaaban RNA waxay fududaysay kordhinta cabitaanka ethanol ee jiirka ethanol-naïve, laakiin maaha jiirka leh taariikhda isticmaalka ethanol ee xad-dhaafka ah.Natiijooyinkani waxay soo jeedinayaan in inta lagu jiro khibradaha hore ee ethanol-cabitaanka, GDNF ee VTA waa la kordhiyay oo waxay ka ilaalisaa horumarinta qaadashada ethanol ee xad-dhaafka ah.Si kastaba ha noqotee, jawaabta ka hortagga koritaanku ee ethanol ayaa burbura ka dib qaadashada ethanol-ka xad-dhaafka ah ee dheeraadka ah iyo ka bixitaanka, taasoo keentay joogto ah, isticmaalka ethanol ee xad dhaafka ah.
