Alaabta

NADPH oxidases waa qoys ka kooban enzymes kuwaas oo dhaliya noocyada ogsijiinta falcelinta (ROS).NOX1 (NADPH oxidase 1) iyo NOX2 oxidases ayaa ah ilaha ugu weyn ee ROS ee gidaarka halbowlaha xaaladaha sida hypertension, hypercholesterolemia, sonkorowga iyo gabowga, sidaas darteed waxay muhiim u yihiin cadaadiska oksaydhka, cillad la'aanta endothelial iyo caabuqa xididdada dhiigga ee hoos yimaada. dib-u-habaynta halbowlaha iyo atherogenesis.Dib-u-eegisgan, waxaanu horumarinay fikradda marka la barbar dhigo isticmaalka antioxidants-ka caadiga ah, joojinta NOX1 iyo NOX2 oxidases waa hab heer sare ah oo lagula dagaalamayo cadaadiska oksaydhka.Waxaan si kooban u sharaxnaa qaar ka mid ah kuwa caadiga ah iyo kuwa soo baxaya ee ka hortagga NADPH oxidase.Intaa waxaa dheer, waxaan muujineynaa doorka muhiimka ah ee NADPH oxidase subunit, p47phox, ee waxqabadka vascular NOX1 iyo NOX2 oxidases, waxaanan soo jeedineynaa sida fahamka wanaagsan ee isdhexgalka molecular ee gaarka ah ay awood u siin karto horumarinta daawooyinka isoform-doorashada cusub si looga hortago. ama daawee cudurada wadnaha wadnaha.