ACES Cas: 7365-82-4 Budada crystalline cad 99% N- (Carbamoylmethyl) taurine
Lambarka buugaagta | XD90108 |
Magaca Alaabta | ACES (N- (2-Acetamido) -2-aminoethanesulfonic acid) |
CAS | 7365-82-4 |
Qaanuunka molecular | C4H10N2O4S |
Miisaanka Molecular | 182.2 |
Faahfaahinta Kaydinta | Ambient |
Xeerka Tarifka La Iswaafajiyay | 29241900 |
Tilmaamaha Alaabta
Hogaamin | <5pm |
pH | 3.5 - 4.5 |
Waxyaalaha biyaha | <0.5% |
Birta | <5pm |
Hadhaaga dabka | <0.1% |
Muuqashada | Budada crystalline cad |
A260 (0.1M biyo) | <0.020 |
A280 (0.1M biyo) | <0.010 |
Assay (Titration) oo ku salaysan qalalan | >99% |
Ujeedada daraasaddan ayaa ahayd in la isbarbar dhigo waxtarka valproate iyo haloperidol ee hoos u dhigista heerka kicinta ee bukaannada ay saameysay waaxda gurmadka.Waxaan u xilsaarnay 80 bukaan oo aadka u kacsan si ay u helaan mid ka mid ah xididada xididka sodium valproate (20 mg/kg) ama haloperidol intramuscular (5 mg/1 ml).Kicinta waxaa lagu cabiray salka iyo 30 min kadib duritaanka kowaad iyadoo la adeegsanayo Miisaanka Qiimaynta Deganaanshaha (ACES), Qayb-hoosaadka Qaybaha Farxsan ee Wanaagsan iyo Dareenka Xun, iyo Miisaanka Dhaqanka Kacdoonka.Bukaannada 80 ee lagu daweeyay sodium valproate, celceliska ± SD qiyaasta qiyaasta waxay ahayd 1541.5 ± 286 mg (qiyaastii 940-2400).Dhibcaha celceliska ka-hortagga ka-hortagga ACES ee salka ilaa 30 min ka dib duritaanka daroogada waxay ahaayeen 4.73 (SD = 1.93) ee kooxda valproate iyo 5.45 (SD = 2.09) ee kooxda haloperidol (P = 0.028).Wax farqi weyn ah looma arag marka la eego celceliska isbeddelada 30 min ka dib faragelinta laba miisaan oo kicin ah oo dheeri ah.Qayb weyn oo ka mid ah bukaannada kooxda haloperidol waxay la kulmeen suuxdin aad u daran (36.2%, P <0.001) iyo calaamadaha extrapyramidal (8.7%, P = 0.007) marka la barbar dhigo kooxda valproate (2.5% suuxdin xoog leh, ma jiro bukaan loogu talagalay calaamadaha extrapyramidal).Natiijooyinka waxay soo jeedinayaan in goobta daaweynta bukaan-socodka ee degdegga ah ee dhimirka, valproate-ka xididada ayaa waxtar u leh sida haloperidol si loo yareeyo kicinta, oo leh muuqaal badbaado oo wanaagsan.