Alaabta

Meelo badan ayaa loo sahamiyaa sidii sidayaal si loo bixiyo asiidhyada nucleic-ka ah ee daweynta.Isku-dubbaridyada caadiga ah waa farmashilojiyadeed oo aan firfircoonayn oo leh shaqada keliya ee keenista xamuulka daweynta.Daraasadani waxay ka warbixisay isku-dhafka is-immolative polycation (DSS-BEN) oo ku salaysan daawada analoogga polyamine N(1), N (11) -bisethylnorspermine (BENSpm).Jeexinta waxaa loo qorsheeyay in ay si laba jeer ah ugu shaqeyso sidii gudbiyaha hiddasidaha iyo dawada lagu beegsanayo dheef-shiid kiimikaad ee polyamine-ka ee kansarka.Isticmaalka isku-darka NMR iyo HPLC, waxaan xaqiijineynaa in polycation-ka is-gubida uu ku dhaco hoos u dhaca unugyada gudaha ee daroogada waalidka BENSpm.BENSpm-ka la sii daayay ayaa hoos u dhigaya heerarka gacanta ee shahwada iyo shahwada waxayna kor u qaadaan polyamine catabolic enzymes spermine / spermidine N (1) -acetyltransferase (SSAT) iyo shahwada oxidase (SMO).Qaybaha isku dhafan waxay sameeyaan polyplexes leh DNA waxayna fududeeyaan isu gudbin hufan.Ka faa'iidaysiga awoodda BENSpm si loo dareensiiyo unugyada kansarka ee TNFa-ku-abuuray apoptos waa, waxaan tusnay in DSS-BEN ay kor u qaaddo waxqabadka dilka unugyada ee daaweynta hidda-wadaha TNFa.Natiijooyinka la soo sheegay waxay ansixiyeen DSS-BEN inay tahay nidaam bixin laba-shaqo leh oo bixin kara hiddo-wadaha daweynta oo wanaajin kara natiijada daawaynta hidda-wadaha taas oo ka dhalatay hoos u dhaca unugyada unugyada ee DSS-BEN ilaa BENSpm iyo saamaynta faa'iidada ee BENSpm ee dambe ee polyamine-ka dysregulated dheef-shiid kiimikaad ee kansarka.