Biosynthesis ee proteoglycans iyo glycosaminoglycans ee joogitaanka p-nitrophenyl-xyloside ayaa la bartay iyadoo la adeegsanayo nidaamka dhaqanka unugga granulosa ee jiirka aasaasiga ah.Ku darida p-nitrophenyl-xyloside ee dhexdhexaadinta dhaqanka unuggu waxay sababtay qiyaastii 700% korodhka [35S] isku darka sulfate (ED50 at 0.03 mM) ee macromolecules, oo ay ku jiraan silsilado chondroitin sulfate oo bilaash ah oo laga bilaabay xyloside iyo proteoglycans hooyo.Silsilada chondroitin sulfate ee bilaashka ah ee laga bilaabay xyloside ayaa ku dhawaad si gaar ah loogu daayay dhexda.Cabbirka molecular ee silsiladaha chondroitin sulfate ayaa hoos uga dhacay 40,000 ilaa 21,000 iyada oo wadarta guud [35S] isku darka sulfate la wanaajiyey, taas oo soo jeedinaysa in la xoojiyey ee chondroitin sulfate ay khalkhalisay habka caadiga ah ee joojinta silsiladda glycosaminoglycan.Biosynthesis of heparan sulfate proteoglycans ayaa la dhimay ku dhawaad 50%, lagana yaabo inay ugu wacan tahay tartanka heerka UDP-sonkorowga.[35S] Isku-darka Sulfate-ka waxaa la xiray ku-darka cycloheximide oo leh nuskii hore ee qiyaastii 2 hr ee joogitaanka xyloside, halka maqnaanshaha xyloside ay ahayd qiyaastii 20 min.Farqiga u dhexeeya waxay u badan tahay inuu ka tarjumayo heerka wareejinta glycosaminoglycan awoodda isku-darka guud ahaan.Heerka wareejinta awoodda isku-darka glycosaminoglycan ee lagu arkay unugyada granulosa ugxan-sidaha ayaa aad uga gaaban kan lagu arkay chondrocytes, taasoo ka tarjumaysa awoodda qaraabada ah ee proteoglycan biosynthetic dhaqdhaqaaqa guud ee dhaqdhaqaaqa dheef-shiid kiimikaadka unugyada.
