Alaabta

(3R,4S,5R,6R)-3,4,5-tris (triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl -2-mid, waa isku-dhismeed caadi ahaan loo isticmaalo isku-dhafka organic iyo sidii koox ilaalin ah oo ku taal berrinkii chemistry. Mid ka mid ah codsiga muhiimka ah ee TBDMS-la ilaaliyo tetrahydro-2H-pyran-2-mid ka mid ah waa adeegsigeeda sida dhismaha dhismaha ee isku-dhafka. oo ah unugyo dabiici ah oo adag.Xarunta ayaa leh goobo badan oo falgal ah kuwaas oo mari kara isbeddello kala duwan oo kooxeed.Kooxda ilaalinta TBDMS (tert-butyldimethylsilyl) ee ku jirta molecule waxay bixisaa xasilooni waxayna u ogolaataa wax ka beddelka xulashada kooxo hawleed gaar ah.Kala duwanaanshiyahani wuxuu ka dhigayaa TBDMS-la ilaaliyo tetrahydro-2H-pyran-2-mid dhexdhexaad ah oo qiimo leh oo ka mid ah isku dhafka alaabta dabiiciga ah, daawooyinka, iyo kiimikooyinka kale ee wanaagsan. Isticmaalka kale ee muhiimka ah ee TBDMS-la ilaaliyo tetrahydro-2H-pyran-2 doorka kooxda ilaalinta alkolada iyo amines ee isku-dhafka dabiiciga ah.Kooxda TBDMS waxaa si xushmad leh loogu dari karaa kooxaha hydroxyl ama amino, iyadoo si wax ku ool ah loo daboolayo inta lagu jiro tillaabooyinka falcelinta ee kala duwan.Ilaalintani waxay ka hortagtaa falcelisyada aan loo baahnayn waxayna hubisaa in isbeddelada la rabo ay ka dhacaan goobaha la rabo.Marka falcelinta la rabo ay dhammaato, kooxda TBDMS si fudud ayaa looga saari karaa, iyada oo soo bandhigaysa hydroxyl asalka ah ama kooxda amino iyada oo aan saameyn ku yeelan shaqooyinka kale ee molecule. karbohaydraytyada.Waxay u ogolaataa ilaalinta xulashada kooxaha hydroxyl ee molecules sonkorta inta lagu jiro falcelinta glycosylation, awood u yeelashada isku-dhafka glycans iyo glycosides adag.Istaraatiijiyadan ilaalinta ayaa si gaar ah muhiim ugu ah kiimikada karbohaydraytyada, halkaas oo kooxo badan oo hydroxyl ah ay joogaan iyo dib-u-doorasho gaar ah ayaa loo baahan yahay. Intaa waxaa dheer, TBDMS-la ilaaliyo tetrahydro-2H-pyran-2-mid ayaa loo isticmaalaa diyaarinta polymers functionalized.Xarunta waxaa lagu dhex dari karaa qaab-dhismeedka polymer, iyadoo siinaya goobo fal-celin ah oo loogu talagalay wax ka beddello dheeraad ah iyo falcelinta isku-xiran.Tani waxay awood u siinaysaa abuurista walxaha polymerka ah ee leh sifooyinka iyo hawlaha, sida xasiloonida wanaajiyay, biocompatibility, iyo siidaynta daawada la xakameeyey. Gabagabadii, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6 -((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-one, ama TBDMS-la ilaaliyo tetrahydro-2H-pyran-2-one, waa isku dhaf ah oo leh codsiyo kala duwan oo ku jira habka organic, gaar ahaan sida dhismaha dhismaha iyo kooxda ilaalinta. .Awooddeeda si ay si xushmad leh u ilaaliso kooxaha shaqeeya oo ay fududayso isbeddellada molecular ee adag waxay ka dhigaysaa qalab qiimo leh oo ku saabsan kiimikooyinka.Baaritaanka joogtada ah iyo sahaminta codsiyadeeda ayaa laga yaabaa inay daaha ka rogto isticmaalka dheeraadka ah waxayna gacan ka geysataa horumarinta kiimikada synthetic iyo sayniska alaabta.