2′-Deoxyuridine Cas:951-78-0
| Lambarka buugaagta | XD90583 |
| Magaca Alaabta | 2'-Deoxyuridine |
| CAS | 951-78-0 |
| Qaanuunka molecular | C9H12N2O5 |
| Miisaanka Molecular | 228.20 |
| Faahfaahinta Kaydinta | 2 ilaa 8 °C |
| Xeerka Tarifka La Iswaafajiyay | 29349990 |
Tilmaamaha Alaabta
| Muuqashada | Caddaan ilaa budo caddaan ah |
| Qiimayn | 99% |
| Meesha dhalaalaysa | 164 - 168 Deg C |
| Khasaare xagga qallajinta | <1.0% |
| Hadhaaga dabka | <0.1% |
Ka faa'iidaysiga nitrogen ee lo'da oo la hagaajiyay ayaa muhiim ah si loo sugo wax soo saarka lo'da oo waara.Maaddaama purines iyo pyrimidines (PP) ay ka kooban yihiin qayb la mahadiyo oo ka mid ah nitrogen-ka rumen, fahamka la wanaajiyey ee nuugista iyo dheef-shiid kiimikaadka dhexe ee PP waa lagama maarmaan.Shaqada hadda jirta waxay qeexaysaa horumarinta iyo ansaxinta hab xasaasi ah oo gaar ah oo loogu talagalay go'aaminta isku mar ee 20 purines (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, thymine). uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), iyo alaabtooda hoos u dhaca (uric acid, allantoin, β-alanine, β-ureidopropionic acid, β-aminoisobutyric acid) ee dhiiga lo'da caanaha.Farsamada ku salaysan dareeraha dareeraha ah ee waxqabadka sare leh oo ay weheliso korantada ionization tandem mass spectrometry (LC-MS/MS) ayaa lagu daray halbeegyada cabbiraadda shaxanka ee shakhsi ahaaneed iyo xeryahooda tixraaca ee isotopically calaamadeysan.Falanqaynta tirada ayaa ka horraysa hab cusub oo daaweyn ka hor ah oo ka kooban roobka ethanol, sifaynta, uumiga iyo dib u habeynta.Halbeegyada kala soocida iyo ogaanshaha inta lagu jiro falanqaynta LC-MS/MS ayaa la baaray.Waxaa la xaqiijiyay in isticmaalka qaab-calibration-Log-callibration halkii ay ka ahaan lahayd qaab toosan ay keentay hoos u dhaca CV-ga iyo la'aanta imtixaan taam ah oo muujiyay dib-u-celin toosan oo qancisa.Habkani wuxuu daboolayaa kala duwanaanshaha u-fiirsashada dheef-shiid kiimikaad kasta iyadoo loo eegayo saamiga dhabta ah, tusaale ahaan guanine: 0.10-5.0 μmol/L, iyo allantoin: 120-500 μmol/L.CV% ee tirada la doortay waxay ka hooseeyeen 25%.Habka waxa uu leeyahay ku celcelin wanaagsan (CV%≤25%) iyo saxnaanta dhexdhexaadka ah (CV%≤25%) iyo soo kabasho aad u fiican (91-107%).Dhammaan dheef-shiid kiimikaadka waxay muujiyeen xasillooni wanaagsan oo muddada-dheer ah iyo xasillooni wanaagsan oo gudaha ah (CV%≤10%).Heerarka kala duwan ee saamaynta matrix buuxda ayaa lagu arkay balaasmaha, kaadida iyo caanaha.Go'aaminta saamaynta matrix qaraabo ah ayaa shaaca ka qaaday in habka uu ku habboon yahay ku dhawaad dhammaan dheef-shiid kiimikaadka PP ee la baaro ee plasma laga soo qaaday halbowleyaasha iyo xididdada cagaarshowga beerka, cagaarshowga iyo gastrosplenic iyo, marka laga reebo dhowr nooc, sidoo kale noocyada kale sida digaaga, doofaarka, mink, dad iyo jiir.
