Alaabta

Xarunta 2-[(2R) -2-hydroxy-3-{[4- (3-oxomorpholin-4-yl) phenyl]amino}propyl]-1H-isoindole-1,3(2H) -dione waa kakan molecule organic oo leh codsiyo suurtagal ah oo ku saabsan farmashiyaha iyo kimistariga daawada. Joogitaanka xudunta isoindole waxay muujineysaa in xaruntani ay leedahay astaamo qaab-dhismeed gaar ah oo ku habboon bayooloji oo laga helay molecules bioactive.Isoindole derivatives ayaa lagu soo warramey inay soo bandhigaan waxqabadyo fara badan oo farmaajo ah, oo ay ku jiraan anti-bararka, antitumor, iyo sifooyinka antimicrobial.The 2-hydroxy-3-{[4- (3-oxomorpholin-4-yl) phenyl]amino}propyl kooxda ku jirta xaruntan waxay ka kooban tahay koox hydroxyl (OH) oo ku xidhan silsilad saddex kaarboon ah, taas oo samaysa laf dhabarta unugyadan.Waxa kale oo ku jira koox phenyl ah oo lagu beddelay unug morpholinone ah.Morpholines ayaa si weyn loogu isticmaalay kimistariga daawada sababtoo ah awoodda ay u leeyihiin inay la falgalaan bartilmaameedyada noolaha ee kala duwan waxaana lagu daray daroogo badan oo leh hawlo kala duwan. Joogitaanka kooxda carbonyl (C=O) ee ku xiran xudunta isoindole waxay soo jeedinaysaa in xaruntan waxay awood u leeyihiin inay u dhaqmaan sidii ligand ama modulator bartilmaameedyada molecular ee gaarka ah ee jidhka dhexdiisa.Xeryahooda Carbonyl-ku-saleysan ayaa loo adeegsaday baaritaanka daroogada si ay ula falgalaan enzymes, reseptors, ama borotiinada ku lug leh hababka cudurrada kala duwan. Si kastaba ha ahaatee, iyada oo aan lahayn macluumaad dheeraad ah oo ku saabsan waxqabadka bayoolojiga ee xaruntan ama bartilmaameedyada gaarka ah, waa adag tahay in la bixiyo sharraxaad dhammaystiran oo ku saabsan isticmaalka iman kara.Cilmi-baaris dheeraad ah iyo tijaabo ayaa loo baahan doonaa si loo go'aamiyo sifooyinka farmasiga ee saxda ah. Gebogebadii, xarunta 2-[(2R) -2-hydroxy-3-{[4- (3-oxomorpholin-4-yl) phenyl]amino}propyl ] -1H-isoindole-1,3 (2H) -dione, oo leh xudunta isoindole iyo kooxaha shaqeynaya, waxay leedahay codsiyo suurtagal ah oo ku saabsan farmashiyaha iyo kimistariga daawada.Isticmaalkeeda gaarka ah iyo habka ay wax u qabato waxay u baahan doontaa in si dheeraad ah loo baadho iyada oo loo marayo cilmi-baadhis iyo tijaabin.