Alaabta

Trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid waa iskudhis kiimiko ah oo leh codsiyo kala duwan, gaar ahaan isku-dhafka dabiiciga ah iyo cilmi-baarista dawooyinka.Qaab dhismeedkeedu wuxuu ka kooban yahay giraanta pyrrolidine oo lagu beddelay koox amino ah iyo tert-butoxycarbonyl (Boc) kooxda ilaalinta atamka nitrogen. Mid ka mid ah isticmaalka aasaasiga ah ee trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3- Aashitada karboxilic waa sida dhisme dhisme ah oo ka mid ah isku-darka unugyo dabiici ah oo kakan.Joogitaanka kooxda amino waxay u ogolaataa isbedel kiimiko oo badan, oo ay ku jiraan amidation, acylation, ama falcelinta isku-xidhka, kuwaas oo udub dhexaad u ah abuurista xeryahooda kala duwan oo leh dawooyin gaar ah ama kiimiko.Kooxda ilaalinta Boc waxay ilaalisaa kooxda amino inta lagu jiro falcelintan, ka hortagga isdhexgalka aan loo baahnayn ama falcelinta dhinaceeda. Intaa waxaa dheer, trans-4-Amino-1-(tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid ayaa si gaar ah qiimo ugu leh isku dhafka peptide-ku salaysan. daroogooyinka.Peptides waa silsilado gaagaaban oo acids amino ah kuwaas oo door muhiim ah ka ciyaara hababka noolaha.Iyada oo si door ah u ilaalinaysa kooxda Boc, xaruntu waxay u adeegi kartaa sida dhismaha amino acid si loo dhiso isku xigxiga peptide.Tani waxay u oggolaaneysaa abuurista dawooyinka peptide-ku-saleysan, kuwaas oo bartilmaameedsan kara bartilmaameedyada molecular gaar ah, sida reseptors ama enzymes, oo wax ka beddelaya dariiqooyin bayooloji oo kala duwan.Daawooyinkani waxay muujiyeen ballanqaad meelaha sida daaweynta kansarka, daaweynta antimicrobial, iyo xanuunka hoormoonka. Kala duwanaanshaha xarunta ayaa sidoo kale ku fidsan awooddeeda sida qalab bilow ah oo loogu talagalay isku-darka molecules organic yar oo leh waxqabad nafley ah.Iyada oo la adeegsanayo kooxaha shaqada iyo stereochemistry ee trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid, cilmi-baarayaashu waxay abuuri karaan analoog ama derivatives leh guryaha dawooyinka la xoojiyay.Xeryahooda wax laga beddelay waxaa lagu baari karaa musharrixiinta daroogada ee suurtagalka ah, lagu qiimeeyo awoodda ay u leeyihiin inay la falgalaan bartilmaameedyada noolaha, ama waxay wax ku bartaan sifooyinkooda farsamo. Waxaa intaa dheer, trans-4-Amino-1-(tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid loo isticmaalo ka kooban tixraac ahaan ujeedooyin gorfaynta.Qaab dhismeedkeeda xasilloon iyo sifooyin si fiican loo yaqaan ayaa ka dhigaya mid qiimo leh sida heerka xakamaynta tayada ee wax soo saarka dawooyinka, hubinta saxnaanta iyo isku halaynta hababka falanqaynta ee loo isticmaalo si loo qiimeeyo nadiifnimada iyo awoodda xeryahooda la xidhiidha gabagabadii, trans-4-Amino-1- (tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid waa iskudhis isku dhafan oo si weyn loogu isticmaalo isku dhafka dabiiciga ah iyo cilmi baarista dawooyinka.Qaab dhismeedka amino acid-ka iyo kooxda ilaalinta ayaa ka dhigaya dhisme lagama maarmaan u ah abuurista molecules organic adag, oo ay ku jiraan peptides iyo musharrixiinta mukhaadaraadka.Baaritaannada socda ee ku saabsan hantideeda iyo wax ka beddelkeeda ayaa sii wadi doona ballaarinta codsiyadeeda waxayna gacan ka geysaneysaa horumarinta wakiilada daweynta cusub.