Alaabta

Trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid waa iskudhis kiimiko oo leh codsiyo kala duwan oo suurtagal ah oo ku saabsan isku-darka organic iyo cilmi-baarista dawooyinka.Waxaa lagu gartaa joogitaanka giraanta pyrrolidine oo lagu beddelay tert-butoxycarbonyl (Boc) kooxda ilaalinta atamka nitrogen iyo kooxda trifluoromethyl ee giraanta phenyl. Mid ka mid ah isticmaalka muhiimka ah ee trans-1- (tert-Butoxycarbonyl) 4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid waa mid dhexdhexaad ah oo ka mid ah xeryahooda kale ee dabiiciga ah.Qaab-dhismeedkeeda gaarka ah iyo kooxaha shaqeeya waxay ka dhigaan dhisme dhisme oo kala duwan oo loogu talagalay dhismaha molecules adag.Kooxda Boc waxay u adeegtaa sidii koox ilaalin ah, taas oo si xushmad leh looga saari karo xaalado falcelin gaar ah si loo muujiyo goobta falcelinta si wax looga beddelo.Tani waxay u oggolaanaysaa isbeddellada dabiiciga ah ee la xakameeyey oo saxda ah. Kooxda trifluoromethyl ee trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid sidoo kale waxay siisaa guryaha muhiimka ah iyo codsiyada suurtagalka ah.Kooxaha Trifluoromethyl waxaa lagu yaqaanaa dabeecadooda elektarooniga ah ee soo jiidashada iyo lipophilicity, taas oo kor u qaadi karta awoodda, xasiloonida dheef-shiid kiimikaadka, iyo bioavailability ee musharaxiinta daroogada.Intaa waxaa dheer, kooxda trifluoromethyl waxay bedeli karaan sifooyinka physicochemical ee xarunta, saameynaya milanka, lipophilicity, iyo soo dhaweynta xiritaanka. Intaa waxaa dheer, trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3- karboksylic acid waxa laga yaabaa inay soo bandhigto dhaqdhaqaaqa noolaha laftiisa ama dawo ahaan.Daroogooyinku waa unugyo aan firfircoonayn oo bayooloji ah kuwaas oo ku dhaca kiimikaad ama isbeddellada enzymatic ee jidhka si loogu beddelo daroogo firfircoon.Xaaladaha qaarkood, kooxda ilaalinta Boc ayaa laga yaabaa in si xushmad leh looga saaro gudaha vivo, iyada oo kicinaysa xarunta si ay u keento saameyn daweyneed oo la rabo phenyl) pyrrolidine-3-carboxylic acid way badan yihiin, baaritaan dheeraad ah iyo cilmi baaris ayaa lagama maarmaan u ah in la sahamiyo awooddeeda buuxda.Tani waxay caadi ahaan ku lug leedahay hagaajinta kimistari daawaynta, daraasaadka xidhiidhka-qaab-dhismeedka, iyo qiimaynta noolaha.Iyagoo si fiican u fahmaya dhismaha xarunta iyo falcelinta, saynisyahannadu waxay qiimayn karaan ku habboonaanshaheeda si loo beegsado cudurro gaar ah ama xaalado, taasoo horseedaysa horumarinta musharraxiinta daroogada cusub ama wakiilada kicinta mustaqbalka.