Tiamulin 98% Cas: 125-65-5
| Lambarka buugaagta | XD91893 |
| Magaca Alaabta | Tiamulin 98% |
| CAS | 125-65-5 |
| Qaabka molecularla | C22H34O5 |
| Miisaanka Molecular | 378.5 |
| Faahfaahinta Kaydinta | -20°C |
| Xeerka Tarifka La Iswaafajiyay | 2918199090 |
Tilmaamaha Alaabta
| Muuqashada | budo cad |
| Asay | 99% min |
| barta dhalaalaysa | 170-1710C |
| alfa | D24 +20° (c = 3 in abs ethanol) |
| Barta karkarinta | 482.8± 45.0 °C (La saadaaliyay) |
| cufnaanta | 1.15±0.1 g/cm3 (La saadaaliyay) |
| milmayn | DMSO:> 10mg/mL (la diiray) |
| pka | 12.91± 0.10 (La saadaaliyay) |
| dhaqdhaqaaqa indhaha | [α]/D +30 ilaa +40° (c=1; CH2Cl2) |
Pleuromutilin waa diterpene oo ay soo saareen dhowr nooc oo baidomycete ah, gaar ahaan nooca Pleurotus, oo la helay 1951. Pleuromutilin waa antibiyootiko awood leh oo aadka u xulashada ah oo firfircoon oo ka hortagaya noocyo kala duwan oo bakteeriyada togan oo Gram ah, oo aan lahayn iska caabin iskutallaab ah fasalada antibiyootiga ee jira sababtuna tahay qaabkeeda gaarka ah. waxqabad.Pleuromutilin waxay joojisaa isku-darka borotiinka iyada oo ku xidhan domain V ee 23S rRNA taasina waxay keentay in la sameeyo analogues badan oo semi-synthetic ah sida antibiyootiga jiilka cusub, sida tiamulin iyo retapamulin.
Pleuromutilins sida tiamulin iyo valnemulin ayaa loo isticmaali jiray in muddo ah daawaynta xoolaha si loogu daweeyo caabuqa doofaarka.Dhawaanahan, pleuromutilin semisynthetic, retapamulin, ayaa loo soo bandhigay daawaynta jirka ee caabuqyada Gram-positive ee aadanaha.Pleuromutilins waxay joojiyaan dhaqdhaqaaqa wareejinta peptidyl ee qaybta 50S ee bakteeriyada ribosomal iyagoo ku xidhaya goobta A.
