Alaabta

Tert-butyl 4- (6-(6- (1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate waa iskudhis awood weyn u leh kimisteriga daawada iyo horumarinta daroogada.Qaab dhismeedkeeda molecular ee kakan ayaa soo jeedinaya codsiyo kala duwan oo suurtagal ah. Xaruntani waxa ay ka kooban tahay piperazine-1-carboxylate core, kaas oo si caadi ah loo isticmaalo kimistariga daawaynta sababtoo ah dabeecadeeda kala duwan iyo fursadaha bartilmaameedka daroogada ee ballaaran.Joogitaanka unugyada piperazine waxay u oggolaaneysaa isdhexgalka soo-dhoweeyayaasha kala duwan iyo enzymes, taasoo ka dhigaysa musharax xiiso leh oo loogu talagalay horumarinta wakiilada daweynta. 6- (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido [2,3-d] pyrimidin-2-yl kooxda ee qaab-dhismeedku waxay bixisaa firfircoonida dawooyinka ee suurtogalka ah.pyrido[2,3-d] pyrimidine devatives ayaa si aad ah loogu bartay ka hortagga bararka, fayraska, iyo guryaha kansarka.Kooxaha cyclopentyl iyo methyl waxay gacan ka geystaan ​​lipophilicity ee xarunta, taas oo kor u qaadi karta awooddeeda gacanta iyo noolaha.Dabacsanaantani waxay qiimo u leedahay kimistariga daawada, maadaama ay awood u siinayso horumarinta xeryahooda awood badan iyo kuwo la xushay.Kooxda pyridin-3-yl ee qaab-dhismeedku waxay u dhaqmaan sidii ligand suurtagal ah oo loogu talagalay soo-dhoweeyayaasha kala duwan, sida G-protein-coupled reseptors (GPCRs).Tani waxay soo jeedinaysaa in xaruntu ay saameyn ku yeelan karto waddooyinka calaamadaynta intracellular waxaana laga yaabaa in lagu sii sahamiyo kartideeda sida modulator ama antagonist of reseptors gaar ah oo ku lug leh xaaladaha cudurka. Qaabdhismeedka guud ee tert-butyl 4- (6- (6-). (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate Awooddeeda horumarinta daweynta cusub.Waxay bixisaa fursado lagu baadho xannibaadda enzym, xidhitaanka reseptor, iyo habaynta hababka noolaha ee kala duwan. Iyadoo sahaminta dheeraadka ah iyo hagaajinta, xaruntani waxay suurtogal u tahay inay u adeegto xarun hogaamineed oo loogu talagalay horumarinta daawooyinka lagu beegsanayo kansarka, caabuqa, ama cudurrada kale.Sifooyinkeeda qaabdhismeed ee gaarka ah iyo waxqabadyada bayoolojiga ee suurtagalka ah waxay ka dhigayaan xarun xiiso leh cilmi-baaris dheeraad ah iyo horumarinta dhinaca kimistariga daawada. Gabagabadii, tert-butyl 4- (6- (6- (1-butoxyvinyl)) -8-cyclopentyl- 5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate waxay ballan qaadaysaa sidii isku-dhismeed isku dhafan oo loogu talagalay horumarinta daroogada.Qaab dhismeedkeeda adag iyo waxqabadyada dawooyinka ee suurtogalka ah waxay ka dhigaan musharax xiiso leh oo baaritaan dheeri ah sida wakiilka suurtagalka ah ee daaweynta cudurrada iyo xaaladaha kala duwan.