Alaabta

Telithromycin ayaa markii ugu horreysay laga bilaabay Jarmalka sidii daweyn afka ah oo maalinle ah oo loogu talagalay caabuqyada neef-mareenka oo ay ku jiraan oof-wareen bulshadu ka hesho, bakteeriyada ba'an ee boronkiitada raaga, sinusitis ba'an iyo qumanka/pharyngitis.Kala soocida semisynthetic ee macrolide erythromycin ee dabiiciga ah ayaa ah ketolide-kii ugu horreeyay ee la suuq geeyo, nooc cusub oo antibiyootik ah oo ka kooban C3-ketone halkii ay ka ahaan lahaayeen kooxda L-cladinose.14-ka xubnood ee giraanta bakteeriyada bakteeriyada waxay ka hortagtaa isku-darka borotiinka bakteeriyada iyagoo ku xiraya laba qaybood oo ka mid ah qaybta 50S ee ribosomes bakteeriyada.Waxay muujinaysaa firfircoonida firfircoon ee vitro ka dhanka ah cudurada caadiga ah ee neef-mareenka oo ay ku jiraan Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis iyo Streptococcus pyogenes iyo sidoo kale cudurada kale ee atypical.Kooxda 3-keto waxay keenaysaa xasilloonida aashitada oo kordhay iyo hoos u dhigista iska caabbinta macrolide-lincosamide-streptogramin B taas oo inta badan lagu arko macrolides.C11-C12 haraaga carbamate ee la beddelay ayaa u muuqda ma aha oo kaliya in la kordhiyo xidhiidhka goobta isku xidhka ee ribosomal, laakiin sidoo kale in la dejiyo xarunta ka soo horjeeda esterase hydrolysis iyo iska ilaalinta caabbinta sababtoo ah ciribtirka macrolides ee unugga by bamka dareeraha ah ee lagu dhejiyay hiddaha mef ee cudurada qaarkood. .Telithromycin labadaba waa horjooge tartan leh iyo substrate CYP3A4.Si kastaba ha ahaatee, si ka duwan dhowr macrolides sida troleandomycin, ma samaynayso xannibaad deggan CYP P-450 Fe2+-nitrosoalkane metabolite-ka dheef-shiid kiimikaadka oo suurtagal ah hepatotoxic.Daawada si fiican ayaa loo dulqaatay oo si fiican loogu qaybiyaa unugyada sambabada, dheecaanka bronki, qumanka iyo candhuufta.Waxay u soo baxday inay si aad ah ugu urursan tahay granules azurophil ee neutrophils polymorphonuclear taas oo sahlaysa gaarsiinta bakteeriyada phagocytosed.