Alaabta

T-Butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate waa unug kiimiko ah oo leh qaab dhismeed adag oo caadi ahaan loo isticmaalo isku-dhafka dabiiciga ah iyo sida koox ilaalin ah oo ku jirta kiimikada karbohaydraytyada.Waxaa lagu yaqaanaa inay awood u leedahay inay si hufan u ilaaliso kooxaha hydroxyl iyo ka hortagga falcelinta aan loo baahnayn inta lagu jiro isbeddelada kiimikada ee kala duwan.Mid ka mid ah isticmaalka aasaasiga ah ee T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- dihydroxyhexanoate waxay ku jirtaa isku-dhafka isku-dhafka dabiiciga ah ee adag.Kooxaha Hydroxyl aad bay u falceliyaan waxayna ku dhici karaan falcelin aan loo baahnayn inta lagu jiro isbeddelka kiimikada.Iyaga oo si xushmad leh u ilaalinaya kooxahan T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate moiety, farmashiyeyaashu waxay xakameyn karaan falcelinta waxayna heli karaan alaabada la rabo.Ka dib marka la dhamaystiro isbeddelada kiimikada ee la rabo, kooxda difaaca ayaa si fudud looga saari karaa, taas oo u oggolaanaysa dib u soo kabashada kooxaha asalka ah ee hydroxyl. Kiimikada carbohydrate, T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate waxaa badanaa loo isticmaalaa ilaalinta unugyada sonkorta.Sonkorta waxaa ku jira kooxo badan oo hydroxyl ah kuwaas oo ka falcelin kara reagen, taasoo keenta badeecooyin aan loo baahnayn.Iyagoo si door ah u ilaalinaya kooxahan hydroxyl ee T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate, farmashiyeyaashu waxay wax ka qaban karaan kooxaha hydroxyl ee soo hadhay iyada oo aan faragelin.Tani waxay u oggolaaneysaa isku-darka sonkorta isku-dhafka ah iyo daraasadda isdhexgalka carbohydrate-protein ama isku-darka glycoconjugates. Intaa waxaa dheer, T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5- Kooxda difaaca dihydroxyhexanoate ayaa inta badan la isticmaalaa inta lagu guda jiro iskudhafka alaabta dabiiciga ah, daawooyinka, iyo xeryahooda kale ee noolaha firfircoon.Ilaalinta wax ku oolka ah iyo guryaha ka-hortagga ayaa u sahlaysa farmashiyeyaasha inay galaan noocyo kala duwan oo unugyo qaab-dhismeed ahaan kala duwan.Ilaalinta kooxaha hydroxyl gaar ah waxay ka caawisaa in la xakameeyo waddooyinka falcelinta iyo gaaritaanka regioselectivity ama stereoselectivity ee la doonayo. Gabagabadii, T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate waa Iskudhis isku dhafan oo si weyn loogu isticmaalo kimistariga dabiiciga ah, gaar ahaan ilaalinta iyo ilaalinta kooxaha hydroxyl.Qaab dhismeedkeeda gaarka ah ayaa u oggolaanaya ilaalinta xulashada, awood u siinaya farmashiyeyaasha inay xakameeyaan falcelinta oo ay helaan alaabada la rabo.Codsiyadeedu waxay u dhexeeyaan isku-dhafka isku-dhafka dabiiciga ah ee isku-dhafan ilaa kiimikooyinka karbohaydraytyada iyo soo-saarka alaabada dabiiciga ah iyo dawooyinka.Awoodda isku dhafka ah ee lagu ilaaliyo kooxaha hydroxyl si hufan waxay ka dhigaysaa qalab qiimo leh oo dhinacyo kala duwan leh oo cilmi baaris iyo horumarin kiimiko ah.