Alaabta

(S) (-) N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine waa isku-darka chiral oo leh codsiyo kala duwan oo ku saabsan farmashiyaha. Hal codsi oo muhiim ah (S) - (-) -N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine waxay ku jirtaa horumarinta xakamaynta dib-u-qaadista serotonin (SSRIs).SSRIs waa daroogo caadi ahaan loo isticmaalo in lagu daweeyo niyad-jabka, xanuunka welwelka, iyo xaaladaha kale ee caafimaadka dhimirka.Xaruntani waxay u shaqeysaa sidii horudhac ama walxo bilaw ah oo ku jira isku-darka xakamaynta dib-u-celinta serotonin ee xulashada, taas oo u oggolaanaysa horumarinta enantiomers gaar ah oo leh sifooyin daaweyneed oo la xoojiyay.Marka lagu daro (S) - (-) N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine ee qaab dhismeedka daroogada, cilmi-baarayaashu waxay ku haboonaan karaan sifooyinkeeda farmashiistaha, sida xiriirka ay u leeyihiin gaadiidleyda serotonin, taasoo keentay waxtarka wanaajinta iyo hoos u dhigista waxyeelada. Intaa waxaa dheer, (S) - (-) N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine waxaa loo isticmaali karaa dhismo dhisme ah oo ka mid ah isku-dhafka kale ee bioactive. xeryahooda.Dabeecaddeeda chiral iyo qaab-dhismeedkeeda kala duwan ayaa ka dhigaya wax bilaw ah oo qiimo leh oo loogu talagalay dhismaha molecules adag.Cilmi-baarayaashu waxay shaqeyn karaan goobo kala duwan oo ku yaala molecule si ay u soo bandhigaan kooxo kala duwan ama wax ka beddelaan stereochemistry si ay u abuuraan musharixiinta daroogada cusub. Intaa waxaa dheer, (S) - (-) N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine ayaa lagu bartay isticmaalka suurtogalka ah ee daaweynta cudurka Parkinson.Cilmi baaris ayaa muujisay in xaruntani ay muujiso firfircoonida dopamine agonist, taasoo la micno ah inay kicin karto daaweeyayaasha dopamine, kuwaas oo inta badan saameeya cudurka Parkinson.Waxaa laga yaabaa inay leedahay awood daweyn si loo yareeyo calaamadaha la xidhiidha xanuunkan neerfaha. Waxaa muhiim ah in la ogaado in (S) - (-) N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine waa mid awood leh. isku dhafan, isticmaalkeedana waa in si taxadar leh loo maareeyaa.Cilmi-baarayaasha iyo xirfadlayaasha ka shaqeeya xaruntan waxay u baahan yihiin inay u hoggaansamaan xeerarka iyo hababka badbaadada si loo hubiyo in si habboon loo maareeyo loona yareeyo khatarta. )propanamine waa xarun qiimo leh oo ku jirta horumarinta serotonin reuptake inhibitors iyo molecules kale oo firfircoon.Dabeecaddeeda cirfiidka ah, qaab-dhismeedkeeda kala duwan, iyo hawlaha daawaynta ee suurtogalka ah ayaa ka dhigaya xannibaad muhiim u ah cilmi-baarista dawooyinka.Daraasadda joogtada ah iyo sahaminta (S) - (-) - N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine waxay gacan ka geysan kartaa horumarinta daawooyinka cusub iyo daaweynta suurtagalka ah ee xanuunada kala duwan.