Alaabta

ATP-gated P2X3 reseptors ayaa muhiim u ah wax-ka-beddeleyaasha nociceptive stimuli waxaana si gaar ah loogu muujiyey dareemayaasha ganglion ee dareemayaasha.In jiirka trigeminal ganglion (TG), P2X3 receptor function si lama filaan ah u wanaajiyey by block pharmacological block of natriuretic peptide receptor-A (NPR-A), qeexaya doorka hor istaagaya suurto gal ah peptides natriuretic endogenous in nociception dhexdhexaadin by P2X3 receptors.Isbeddel la'aanta ku jirta muujinta borotiinka P2X3 waxay muujinaysaa habayn isku dhafan oo hababka hoos u dhigista shaqada P2X3 aan caddayn. blocker anantin.Markaa, waxaanu baarnay isbeddelada qaybinta soo-dhowaynta P2X3 ee qaybta xuubka xuubka xuubka, xaaladdooda fosforyaalka, iyo sidoo kale shaqadooda oo leh xirmo balastar ah.Daahitaanka bilawga P2X3 dareen-celinta waxay ahayd hal hab oo loogu talagalay kobcinta anantin-ku-abuuray waxqabadka P2X3.Anant ee arjiga ayaa sababay dib-u-qaybinta soo-dhoweynta P2X3 ee doorbida qaybta raft-ga iyo hoos u dhaca P2X3 serine phosphorylation, laba dhacdo oo aan isku tiirsanayn.Xakamaynta borotiinka kinase-ku-tiirsan ee cGMP iyo garaacista siRNA-dhexdhexaadin ah ee BNP ayaa la jaan qaaday saameynta anantin.Waxaan ku muujinnay in jiirka trigeminal neurons endogenous BNP uu u dhaqmo soo-qabayaasha NPR-A si loo go'aamiyo niyad-jabka isku-dhafka ah ee shaqada soo-dhoweynta P2X3.Xakamaynta tonic ee waxqabadka reseptor P2X3 ee wadooyinka BNP/NPR-A/PKG waxay ku dhacdaa laba habab oo kala duwan: P2X3 serine fosforyaalka iyo dib-u-qeybiyaha reseptor-ka ee qaybaha xuubka aan raft-ka ahayn.Habkan cusub ee kantaroolka soo-dhoweynta ayaa laga yaabaa inuu noqdo bartilmaameed loogu talagalay daraasadaha mustaqbalka ee loogu talagalay hoos u dhigista waxqabadka soo-dhoweynta P2X3 ee xanuunka joogtada ah.