Alaabta

Si loo sahamiyo maaddooyinka cusub ee platinum-ku-saleysan ka-hortagga kansarka kuwaas oo ka duwan qaab-dhismeedka iyo habka is-dhexgalka ee cisplatin-dhaqameedka iyada oo la samaynayo laba-geesoodka intrastrand 1,2 GpG, isku-dhafka platinum+ DNA-ga monofunctional oo leh is-dhexgal ballaaran oo aan wadajir ahayn ayaa la darsay.Waxaa la sheegay in wakiilada platinum (II) ee ku salaysan testosterone monofunctional ay soo bandhigaan waxqabadka sare ee kansarka.Waxaa intaa dheer, waxaa sidoo kale la ogaaday in wakiilada platinum-ku-salaysan ee testosterone ay keeni karaan helix DNA-da si ay u maraan fur-furan iyo foorarsiga wakiilada platinum-ku-salaysan ee aan testosterone ahayn.Si kastaba ha noqotee, hababka isdhexgalka ee wakiilada platinum-ka ee DNA-da heerka atomiga ah ayaan weli caddayn ilaa hadda. Shaqada hadda, waxaan isticmaalnay jilitaanka molecular dynamics (MD) iyo xisaabinta isbeddelka DNA-ga si loo barto sifooyinka DNA-da ee testosterone- platinum+DNA ku salaysan, platinum+DNA-ku-salaysan testosterone oo la hagaajiyay iyo platinum+DNA-ku-salaysan testosterone-ka.Natiijooyinku waxay muujinayaan in isdhexgalka isdhexgalka ee wakiilka platinum-ku-salaysan ee dabacsan ee testosterone-ku-salaysan ee DNA-da ay keeni karto qallooc weyn oo qaabaysan DNA-da marka loo eego is-dhexgalka weji-gaaban ee wakiilka platinum-ka adag ee testosterone-ku-salaysan ee leh DNA molecule.Baadhitaano dheeraad ah oo ku saabsan wakiilka platinum-ku salaysan ee aan testosterone-ku-salaysan ayaa muujinaya dhacdada isbeddelka isbeddelka ah ee DNA-da sababtoo ah maqnaanshaha ligand testosterone ee wakiilkaas.Iyada oo ku saleysan falanqaynta dhaqdhaqaaqa DNA-da, dhaqdhaqaaqyada saldhigga DNA ee la xidhiidha isbeddelada cabbirka DNA-da iyo burburinta bond bond ee lammaanaha DNA-da ayaa sidoo kale looga hadlay shaqadan. platinum + DNA-ku-salaysan ee testosterone-ku-salaysan, taas oo ka duwan is-dhexgalka weji-gacan ee ay sababtay isku-xiraha adag ee wakiilka platinum-ku-saleysan testosterone.Baadhitaannada hadda jira waxay bixiyaan macluumaad faa'iido leh oo ku saabsan is-beddelka DNA-da ee saameeya isku-dhafka platinum-ku-salaysan ee testosterone ee heerka atomiga.