Penicillin G potassium cusbo CAS:113-98-4 99% budo cad
| Lambarka buugaagta | XD90351 |
| Magaca Alaabta | Penicillin G potassium cusbada |
| CAS | 113-98-4 |
| Qaanuunka molecular | C16H17KN2O4S |
| Miisaanka Molecular | 372.48 |
| Faahfaahinta Kaydinta | Ambient |
| Xeerka Tarifka La Iswaafajiyay | 29411000 |
Tilmaamaha Alaabta
| Khasaare xagga qallajinta | <1.0% |
| Midabka Xalka | Aan ka midab badanayn xoojinta Y2 ama YG2 ee baaxadda tixraaca |
| pH | 5-7.5 |
| Walxaha laxidhiidha | <1.0% |
| Qiimayn | 99% |
| Awoodda | 1440 - 1680u/mg |
| Muuqashada | Caddaan ilaa cad cad budo crystalline ah |
| Cadaynta Xalka | In aan ka badnayn opalescent ka joojinta tixraaca 1 |
| Gudbinta | NLT 90% |
| Butyl acetate | NMT 0.05% |
| Butanol | NMT 0.12% |
e hore loogu sharaxay in molecule autoinducer, oo loo aqoonsaday inuu yahay 1,3-diaminopropane (1,3-DAP), ay sirayso Penicillium chrysogenum iyo Acremonium chrysogenum.Isticmaalka dhaqamada fermentor-ka ee pH ay maamusho waxaan ku aragnay shaqadan in 1,3-DAP iyo spermidine ay si cad u kiciyaan biosynthesis ee benzylpenicillin ee P. chrysogenum, labadaba qeexan iyo warbaahinta soosaarka penicillin ee adag.Labada 1,3-DAP iyo spermidine, laakiin aan ahayn putrescine (1,4-diaminobutane), waxay soo saaraan koror aad u daran heerarka qoraalka ee penicillin biosynthetic genes pcbAB, pcbC iyo penDE.Polyamines-yadani ma saameeyaan muujinta pH-stress regulator pacC gene, sidaas darteed marka laga reebo in saameynta 1,3-DAP iyo spermidine ay sabab u tahay isbeddelka habka xakamaynta pH.Muujinta saddexda gen ee penicillin biosynthetic ayaa si aad ah hoos loogu dhigaa mutant laeA-garaaca ee P. chrysogenum, kaas oo soo saara heerar aad u hooseeya ee benzylpenicillin.Waxa xiiso leh, 1,3-DAP iyo shahwada shahwada waxay dib u soo celiyaan saamaynta isbeddelka garaaca ee laeA, iyagoo si buuxda u soo celinaya heerarka soosaarka penicillin.Intaa waxaa dheer, 1,3-DAP iyo shahwada shahwada waxay xoojiyeen muujinta laeA ee culeyska waalidka waxayna dib u soo celiyeen heerarka qoraallada laeA ee mutant-garaaca laeA.Isku soo wada duuboo natiijooyinkani waxay muujinayaan in saameynta kicinta ee molecules inducer 1,3-DAP iyo spermidine la sameeyo, ugu yaraan qayb ahaan, iyada oo loo marayo kicinta muujinta laeA, nidaamiye caalami ah oo u dhaqma epigenetically on muujinta hiddo-shiid kiimikaadka sare. dib u habeynta heterochromatin.
