Alaabta

N- (5-bromo- [1,3] thiazolo [4,5-b] pyridin-2-yl) benzamide waa kiimiko kiimiko ah oo leh codsiyo suurtagal ah oo ku saabsan cilmi-baarista dawooyinka, gaar ahaan horumarinta dawooyinka cusub.Qaab-dhismeedkeeda molecular ee gaarka ah oo ay ku jiraan thiazolo [4,5-b] pyridine iyo benzamide moieties waxay bixiyaan fursado loogu talagalay codsiyada daawooyinka kala duwan. Mid ka mid ah isticmaalka aasaasiga ah ee N- (5-bromo-[1,3] thiazolo [4,5-b ]pyridin-2-yl) benzamide waa farmakoophore ahaan, qaab dhismeed muhiim ah oo la falgala bartilmaameedyada noolaha ee jirka.Joogitaanka giraanta thiazolo [4,5-b] pyridine waxay u oggolaaneysaa xarunta in loo qaabeeyo sidii ligand suurtagal ah oo lagu xiro bartilmaameedyo gaar ah, sida reseptors ama enzymes, oo ku lug leh hababka cudurrada kala duwan.Iyagoo wax ka beddelaya beddelka giraanta thiazolo [4,5-b] pyridine ama kooxda benzamide, saynisyahannadu waxay habayn karaan isdhexgalka xarunta si ay u beegsadaan waddooyin gaar ah ama cudurro.Xaruntani waxay u adeegi kartaa barta bilawga ah ee isku-dhafka iyo hagaajinta xeryahooda sunta rasaasta ee barnaamijyada helitaanka daroogada.Intaa waxaa dheer, N- (5-bromo-[1,3] thiazolo [4,5-b] pyridin-2-yl) benzamide waxaa loo isticmaali karaa daraasadaha xiriirka-shaqo-dhismeedka (SAR).Adiga oo isku dubaridinaya kala-soocida iyo analoogyada xaruntan, cilmi-baarayaashu waxay qiimeyn karaan sida isbeddellada kala duwan ay u saameeyaan firfircoonida nafleyda iyo awoodda.Macluumaadkan ayaa muhiim u ah naqshadeynta macquulka ah ee musharixiinta cusub ee daroogada oo leh waxtarka wanaajinta iyo hoos u dhigista waxyeellooyinka. Marka lagu daro helitaanka daroogada, N- (5-bromo-[1,3] thiazolo [4,5-b] pyridin-2- yl) Benzamide waxay ka heli kartaa codsiga bayoolajiga kiimikada iyo daraasadaha aqoonsiga bartilmaameedka.Waxa loo isticmaali karaa sidii qalab ka kooban qiimaynta bayoolojiga si loo caddeeyo shaqada bartilmaameedyada gaarka ah iyo waddooyinka hababka gacanta.Iyadoo la baranayo saameynta xaruntan ee hababka gacanta, saynisyahannadu waxay heli karaan fikrado qiimo leh oo ku saabsan hababka asaasiga ah ee cudurrada waxayna awood u leeyihiin inay aqoonsadaan bartilmaameedyada daaweynta cusub. Intaa waxaa dheer, N- (5-bromo-[1,3] thiazolo [4,5-b) ]pyridin-2-yl) benzamide waxaa laga yaabaa in lagu shaqaaleysiiyo cilmi-baarista kimistariga daawada ee horumarinta wakiilada kansarka.Thiazolo [4,5-b] derivatives pyridine waxay muujiyeen ballanqaad ah in la joojiyo dariiqyada kansarka ee kala duwan, sida kinase borotiinka oo ku lug leh koritaanka unugyada iyo badbaadada.Marka lagu daro beddelka bromine-ka iyo kooxda benzamide, awoodda xarunta iyo xulashada sida wakiilka ka hortagga kansarka ayaa la sii baadhi karaa oo la hagaajin karaa. -2-yl) benzamide waa xarun qiimo leh oo leh codsiyada suurtagalka ah ee cilmi-baarista dawooyinka.Qaab dhismeedkeeda gaarka ah waxa uu fursado ku siinaya naqshadaynta iyo isku xidhka xeryahooda sunta rasaasta, daraasaadka SAR, aqoonsiga bartilmaameedka, iyo horumarinta wakiilada kansarka.Kala-duwanaanshaha xarunta iyo kartida ay u leedahay helitaanka maandooriyaha ayaa muujinaya muhiimada ay u leedahay horumarinta qaybta kimisteriga daawada iyo wax ku biirinta suurtagalka ah ee ay ku kordhinayso horumarinta waxqabadyo daweyn oo cusub.