Alaabta

Hababka lagu daweeyo T2DM, cudur lagu garto laba cilladood oo ah cilladda unugyada islet-ka iyo iska caabbinta insulin, waxaa ka mid ah wakiilada kordhiya dheecaanka insulinta ee xameetida ( secretetagogues ), wakiilada kordhiya dareenka xubnaha bartilmaameedka ah ee insulin (dareenka), iyo Wakiilada hoos u dhigaya heerka nuugista gulukooska ee habka dheef-shiidka.Gaar ahaan, lysine ee booska 34 ayaa lagu beddelay arginine, iyo lysine booska 26 waxaa lagu beddelay silsilad C16 acyl iyada oo loo marayo glutamoyl spacer.Liraglutide waxay ka soo qaadaa iska caabinteeda hoos u dhaca DPP-4 iyada oo u janjeerta inay samaysato miceles iyo inay ku xidho albumin.Si ka duwan kii hore ee exenatide, oo u baahan laba irbadood oo subcutaneous maalinle ah ka hor cuntada ugu horreysa iyo tan ugu dambeysa ee maalinta, liraglutide waxaa loo oggolaaday sidii nidaam daweyn maalintiiba hal mar ah waxaana loo isticmaali karaa in lagu daro metformin ama sulfonylurea bukaannada aan ku filneyn xakamaynta glycemic monotherapy ama isku darka laba-therapy.Waxa kale oo la oggolaaday iyada oo lagu daray labada daawaynta ee metformin iyo thiazolidinedione ee bukaannada aan ku filnayn xakamaynta glycemic.Liraglutide waxay soo bandhigtay awoodda xiritaanka ee 61 pM (EC50= 55 pM ee GLP-1) ee soo-dhowaynta bini'aadamka ee GLP-1.